Lack of thrombopoietin potentiation of platelet collagen activation in the first trimester is associated with preeclampsia

Roger C. Carroll, Ricky L. Owers, Robert Elder, Mark D. Hennessey, Stephen K. Patteson, Carolyn C. Snider, Robert A. Muenchen

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

To determine whether a difference exists in platelet reactivity to collagen and potentiation by thrombopoietin (TPO) between preeclamptic and non-preeclamptic patients, 187 first trimester pregnant patients were prospectively followed through pregnancy. Citrated blood, drawn at first (<14 weeks estimated gestational age) and third trimesters (>28 weeks), when patients were admitted for delivery, and 4-6 weeks postpartum, was assayed by a Whole Blood Impedance Aggregometer measuring platelet activation by 0.4 μg/ml collagen, ±10 ng/ml TPO. There was no significant difference in 1st trimester platelet collagen activation by unpaired t-test between groups. Significant TPO potentiation of collagen activation (P<0.05, paired t-test) was observed in non-preeclamptic patients at the first and third trimesters. In contrast, preeclamptic patients' platelets show no significant (P>0.8, paired t-test) TPO potentiation at any time. While the mechanism for this difference in thrombopoietin potentiation of platelet activation by collagen as early as the first trimester is unknown, it may be one of the initiating events in this syndrome.

Original languageEnglish (US)
Pages (from-to)51-54
Number of pages4
JournalThrombosis Research
Volume116
Issue number1
DOIs
StatePublished - Jan 1 2005

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Thrombopoietin
Platelet Activation
First Pregnancy Trimester
Pre-Eclampsia
Collagen
Electric Impedance
Postpartum Period
Blood Platelets
Pregnancy

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Lack of thrombopoietin potentiation of platelet collagen activation in the first trimester is associated with preeclampsia. / Carroll, Roger C.; Owers, Ricky L.; Elder, Robert; Hennessey, Mark D.; Patteson, Stephen K.; Snider, Carolyn C.; Muenchen, Robert A.

In: Thrombosis Research, Vol. 116, No. 1, 01.01.2005, p. 51-54.

Research output: Contribution to journalArticle

Carroll, Roger C. ; Owers, Ricky L. ; Elder, Robert ; Hennessey, Mark D. ; Patteson, Stephen K. ; Snider, Carolyn C. ; Muenchen, Robert A. / Lack of thrombopoietin potentiation of platelet collagen activation in the first trimester is associated with preeclampsia. In: Thrombosis Research. 2005 ; Vol. 116, No. 1. pp. 51-54.
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