Language dominance determined by magnetic source imaging

A comparison with the Wada procedure

Joshua I. Breier, P. G. Simos, G. Zouridakis, James Wheless, L. J. Willmore, J. E.C. Constantinou, W. W. Maggio, A. C. Papanicolaou

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

Objective: To evaluate the validity of data derived from magnetic source imaging (MSI) regarding cerebral dominance for language in patients with intractable seizure disorder. Method: The authors performed functional imaging of the receptive language cortex using a whole-head neuromagnetometer in 26 consecutive epilepsy patients who also underwent the intracarotid amobarbital (Wada) procedure. During MSI recordings, patients engaged in a word recognition task. This task was shown previously to activate language areas in normal adults as well as in patients who undergo intraoperative language mapping, allowing confirmation of MSI findings. Language laterality indices were formed for both the Wada and the MSI procedures. In addition, clinical judgments regarding cerebral dominance for language were made using the two methods by independent raters. Results: Cluster analysis indicated excellent agreement between the quantitative MSI and Wada indices. Rater judgments showed almost complete agreement as well. Conclusion: MSI is a promising method for determining cerebral dominance for language.

Original languageEnglish (US)
Pages (from-to)938-945
Number of pages8
JournalNeurology
Volume53
Issue number5
StatePublished - Sep 22 1999

Fingerprint

Language
Cerebral Dominance
Epilepsy
Amobarbital
Cluster Analysis
Head

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Breier, J. I., Simos, P. G., Zouridakis, G., Wheless, J., Willmore, L. J., Constantinou, J. E. C., ... Papanicolaou, A. C. (1999). Language dominance determined by magnetic source imaging: A comparison with the Wada procedure. Neurology, 53(5), 938-945.

Language dominance determined by magnetic source imaging : A comparison with the Wada procedure. / Breier, Joshua I.; Simos, P. G.; Zouridakis, G.; Wheless, James; Willmore, L. J.; Constantinou, J. E.C.; Maggio, W. W.; Papanicolaou, A. C.

In: Neurology, Vol. 53, No. 5, 22.09.1999, p. 938-945.

Research output: Contribution to journalArticle

Breier, JI, Simos, PG, Zouridakis, G, Wheless, J, Willmore, LJ, Constantinou, JEC, Maggio, WW & Papanicolaou, AC 1999, 'Language dominance determined by magnetic source imaging: A comparison with the Wada procedure', Neurology, vol. 53, no. 5, pp. 938-945.
Breier JI, Simos PG, Zouridakis G, Wheless J, Willmore LJ, Constantinou JEC et al. Language dominance determined by magnetic source imaging: A comparison with the Wada procedure. Neurology. 1999 Sep 22;53(5):938-945.
Breier, Joshua I. ; Simos, P. G. ; Zouridakis, G. ; Wheless, James ; Willmore, L. J. ; Constantinou, J. E.C. ; Maggio, W. W. ; Papanicolaou, A. C. / Language dominance determined by magnetic source imaging : A comparison with the Wada procedure. In: Neurology. 1999 ; Vol. 53, No. 5. pp. 938-945.
@article{cf49f05558f04598b490a067d6daeff8,
title = "Language dominance determined by magnetic source imaging: A comparison with the Wada procedure",
abstract = "Objective: To evaluate the validity of data derived from magnetic source imaging (MSI) regarding cerebral dominance for language in patients with intractable seizure disorder. Method: The authors performed functional imaging of the receptive language cortex using a whole-head neuromagnetometer in 26 consecutive epilepsy patients who also underwent the intracarotid amobarbital (Wada) procedure. During MSI recordings, patients engaged in a word recognition task. This task was shown previously to activate language areas in normal adults as well as in patients who undergo intraoperative language mapping, allowing confirmation of MSI findings. Language laterality indices were formed for both the Wada and the MSI procedures. In addition, clinical judgments regarding cerebral dominance for language were made using the two methods by independent raters. Results: Cluster analysis indicated excellent agreement between the quantitative MSI and Wada indices. Rater judgments showed almost complete agreement as well. Conclusion: MSI is a promising method for determining cerebral dominance for language.",
author = "Breier, {Joshua I.} and Simos, {P. G.} and G. Zouridakis and James Wheless and Willmore, {L. J.} and Constantinou, {J. E.C.} and Maggio, {W. W.} and Papanicolaou, {A. C.}",
year = "1999",
month = "9",
day = "22",
language = "English (US)",
volume = "53",
pages = "938--945",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Language dominance determined by magnetic source imaging

T2 - A comparison with the Wada procedure

AU - Breier, Joshua I.

AU - Simos, P. G.

AU - Zouridakis, G.

AU - Wheless, James

AU - Willmore, L. J.

AU - Constantinou, J. E.C.

AU - Maggio, W. W.

AU - Papanicolaou, A. C.

PY - 1999/9/22

Y1 - 1999/9/22

N2 - Objective: To evaluate the validity of data derived from magnetic source imaging (MSI) regarding cerebral dominance for language in patients with intractable seizure disorder. Method: The authors performed functional imaging of the receptive language cortex using a whole-head neuromagnetometer in 26 consecutive epilepsy patients who also underwent the intracarotid amobarbital (Wada) procedure. During MSI recordings, patients engaged in a word recognition task. This task was shown previously to activate language areas in normal adults as well as in patients who undergo intraoperative language mapping, allowing confirmation of MSI findings. Language laterality indices were formed for both the Wada and the MSI procedures. In addition, clinical judgments regarding cerebral dominance for language were made using the two methods by independent raters. Results: Cluster analysis indicated excellent agreement between the quantitative MSI and Wada indices. Rater judgments showed almost complete agreement as well. Conclusion: MSI is a promising method for determining cerebral dominance for language.

AB - Objective: To evaluate the validity of data derived from magnetic source imaging (MSI) regarding cerebral dominance for language in patients with intractable seizure disorder. Method: The authors performed functional imaging of the receptive language cortex using a whole-head neuromagnetometer in 26 consecutive epilepsy patients who also underwent the intracarotid amobarbital (Wada) procedure. During MSI recordings, patients engaged in a word recognition task. This task was shown previously to activate language areas in normal adults as well as in patients who undergo intraoperative language mapping, allowing confirmation of MSI findings. Language laterality indices were formed for both the Wada and the MSI procedures. In addition, clinical judgments regarding cerebral dominance for language were made using the two methods by independent raters. Results: Cluster analysis indicated excellent agreement between the quantitative MSI and Wada indices. Rater judgments showed almost complete agreement as well. Conclusion: MSI is a promising method for determining cerebral dominance for language.

UR - http://www.scopus.com/inward/record.url?scp=0033595522&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033595522&partnerID=8YFLogxK

M3 - Article

VL - 53

SP - 938

EP - 945

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 5

ER -