Large Unresponsive Zones Appear in Cat Somatosensory Cortex Immediately After Ulnar Nerve Cut

Cheng Xiang Li, Robert Waters, Akinniran Oladehin, Eldridge F. Johnson, Carl A. McCandlish, Robert W. Dykes

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The organization of the primary somatosensory cortex innervated by the ulnar nerve was studied before and immediately after ulnar nerve transection in 11 cats electrophysiologically mapped under Nembutal or Ketamine anesthesia. The cortex was reexamined a second time beginning 42 hr after nerve transection in four cats anesthetized with Nembutal. One additional sham-operated control was also mapped. The region of cortex formerly served by the ulnar nerve remained largely unresponsive to somatic stimulation independent of the type of anesthetic used during recording. Nonetheless, animals anesthetized with Ketamine had more new responsive sites in deafferented cortex following nerve cut than cats anesthetized with Nembutal. New responses, when observed, were evoked by stimulation of a region of skin adjacent to the region served by the ulnar nerve. These findings suggest that the immediate response to deafferentation of somatosensory cortex is a limited acquisition of novel responses restricted to a region immediately adjacent to cortex containing normal afferent input.

Original languageEnglish (US)
Pages (from-to)233-247
Number of pages15
JournalCanadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
Volume21
Issue number3
DOIs
StatePublished - Jan 1 1994

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Ulnar Nerve
Somatosensory Cortex
Cats
Pentobarbital
Ketamine
Anesthetics
Anesthesia
Skin

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Large Unresponsive Zones Appear in Cat Somatosensory Cortex Immediately After Ulnar Nerve Cut. / Li, Cheng Xiang; Waters, Robert; Oladehin, Akinniran; Johnson, Eldridge F.; McCandlish, Carl A.; Dykes, Robert W.

In: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, Vol. 21, No. 3, 01.01.1994, p. 233-247.

Research output: Contribution to journalArticle

Li, Cheng Xiang ; Waters, Robert ; Oladehin, Akinniran ; Johnson, Eldridge F. ; McCandlish, Carl A. ; Dykes, Robert W. / Large Unresponsive Zones Appear in Cat Somatosensory Cortex Immediately After Ulnar Nerve Cut. In: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. 1994 ; Vol. 21, No. 3. pp. 233-247.
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