Lateralized basal ganglia vulnerability to pesticide exposure in asymptomatic agricultural workers

Mechelle M. Lewis, Nicholas W. Sterling, Guangwei Du, Eun Young Lee, Grace Shyu, Michael Goldenberg, Thomas Allen, Christy Stetter, Lan Kong, Shedra Amy Snipes, Byron Jones, Honglei Chen, Richard B. Mailman, Xuemei Huang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Pesticide exposure is linked to Parkinson's disease, a neurodegenerative disorder marked by dopamine cell loss in the substantia nigra of the basal ganglia (BG) that often presents asymmetrically. We previously reported that pesticideexposed agricultural workers (AW) have nigral diffusion tensor imaging (DTI) changes. The current study sought to confirm this finding, and explore its hemisphere and regional specificity within BG structures using an independent sample population. Pesticide exposure history, standard neurological exam, high-resolution magnetic resonance imaging (T1/T2-weighted and DTI), and [123I]ioflupane SPECT images (to quantify striatal dopamine transporters) were obtained from 20 AW with chronic pesticide exposure and 11 controls. Based on median cumulative days of pesticide exposure, AW were subdivided into high (AWHi, n=10) and low (AWLo, n=10) exposure groups. BG (nigra, putamen, caudate, and globus pallidus [GP]) fractional anisotropy (FA), mean diffusivity (MD), and striatal [123I]ioflupane binding in each hemisphere were quantified, and compared across exposure groups using analysis of variance. Left, but not right, nigral and GP FA were significantly lower in AW compared with controls (p's <.029). None of the striatal (putamen and caudate) DTI or [123I]ioflupane binding measurements differed between AW and controls. Subgroup analyses indicated that significant left nigral and GP DTI changes were present only in the AWHi (p ≤.037) but not the AWLo subgroup. AW, especially those with higher pesticide exposure history, demonstrate lateralized microstructural changes in the nigra and GP, whereas striatal areas appear relatively unaffected. Future studies should elucidate how environmental toxicants cause differential lateralized- and regionally specific brain vulnerability.

Original languageEnglish (US)
Pages (from-to)170-178
Number of pages9
JournalToxicological Sciences
Volume159
Issue number1
DOIs
StatePublished - Jan 1 2017

Fingerprint

Diffusion tensor imaging
Basal Ganglia
Pesticides
Corpus Striatum
Globus Pallidus
Diffusion Tensor Imaging
Substantia Nigra
Putamen
Anisotropy
History
Dopamine Plasma Membrane Transport Proteins
Magnetic resonance
Analysis of variance (ANOVA)
Single-Photon Emission-Computed Tomography
Dopamine
Brain
Neurodegenerative Diseases
Parkinson Disease
Farmers
Analysis of Variance

All Science Journal Classification (ASJC) codes

  • Toxicology

Cite this

Lewis, M. M., Sterling, N. W., Du, G., Lee, E. Y., Shyu, G., Goldenberg, M., ... Huang, X. (2017). Lateralized basal ganglia vulnerability to pesticide exposure in asymptomatic agricultural workers. Toxicological Sciences, 159(1), 170-178. https://doi.org/10.1093/TOXSCI/KFX126

Lateralized basal ganglia vulnerability to pesticide exposure in asymptomatic agricultural workers. / Lewis, Mechelle M.; Sterling, Nicholas W.; Du, Guangwei; Lee, Eun Young; Shyu, Grace; Goldenberg, Michael; Allen, Thomas; Stetter, Christy; Kong, Lan; Snipes, Shedra Amy; Jones, Byron; Chen, Honglei; Mailman, Richard B.; Huang, Xuemei.

In: Toxicological Sciences, Vol. 159, No. 1, 01.01.2017, p. 170-178.

Research output: Contribution to journalArticle

Lewis, MM, Sterling, NW, Du, G, Lee, EY, Shyu, G, Goldenberg, M, Allen, T, Stetter, C, Kong, L, Snipes, SA, Jones, B, Chen, H, Mailman, RB & Huang, X 2017, 'Lateralized basal ganglia vulnerability to pesticide exposure in asymptomatic agricultural workers', Toxicological Sciences, vol. 159, no. 1, pp. 170-178. https://doi.org/10.1093/TOXSCI/KFX126
Lewis, Mechelle M. ; Sterling, Nicholas W. ; Du, Guangwei ; Lee, Eun Young ; Shyu, Grace ; Goldenberg, Michael ; Allen, Thomas ; Stetter, Christy ; Kong, Lan ; Snipes, Shedra Amy ; Jones, Byron ; Chen, Honglei ; Mailman, Richard B. ; Huang, Xuemei. / Lateralized basal ganglia vulnerability to pesticide exposure in asymptomatic agricultural workers. In: Toxicological Sciences. 2017 ; Vol. 159, No. 1. pp. 170-178.
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