Lesion distribution among 281 patients with sporadic neuralgic amyotrophy

Mark Ferrante, Asa J. Wilbourn

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Introduction: The muscles commonly affected by neuralgic amyotrophy (NA) are well known, but the location of the responsible lesions is less clear (plexus versus extraplexus). Methods: We report the lesion locations in 281 NA patients as determined by extensive electrodiagnostic (EDX) testing. Results: Our 281 patients had 322 bouts of NA, 57 of which were bilateral, for a total of 379 assessable events. A single nerve was involved in 174 (46%), and 205 (54%) were multifocal. EDX testing identified 703 individual lesions: 699 neuropathies and 4 supraclavicular radiculoplexus lesions. Conclusions: The frequency of nerve involvement reflects the motor predilection of NA. Involvement of pure motor nerves exceeded that of predominantly motor nerves, both of which far exceeded involvement of more evenly mixed sensorimotor nerves. Cutaneous sensory nerves were least commonly involved. Because of the common C5–C6 innervation, NA often mimics an upper plexus lesion. Extraplexus nerve involvement far exceeded plexus involvement. Distal motor branch involvement explains the severe single-muscle wasting and weakness often observed. Muscle Nerve 55: 858–861, 2017.

Original languageEnglish (US)
Pages (from-to)858-861
Number of pages4
JournalMuscle and Nerve
Volume55
Issue number6
DOIs
StatePublished - Jun 1 2017

Fingerprint

Brachial Plexus Neuritis
Muscles
Muscle Weakness
Skin

All Science Journal Classification (ASJC) codes

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

Cite this

Lesion distribution among 281 patients with sporadic neuralgic amyotrophy. / Ferrante, Mark; Wilbourn, Asa J.

In: Muscle and Nerve, Vol. 55, No. 6, 01.06.2017, p. 858-861.

Research output: Contribution to journalArticle

@article{03d2cd142f714a948913e98422d1adbf,
title = "Lesion distribution among 281 patients with sporadic neuralgic amyotrophy",
abstract = "Introduction: The muscles commonly affected by neuralgic amyotrophy (NA) are well known, but the location of the responsible lesions is less clear (plexus versus extraplexus). Methods: We report the lesion locations in 281 NA patients as determined by extensive electrodiagnostic (EDX) testing. Results: Our 281 patients had 322 bouts of NA, 57 of which were bilateral, for a total of 379 assessable events. A single nerve was involved in 174 (46{\%}), and 205 (54{\%}) were multifocal. EDX testing identified 703 individual lesions: 699 neuropathies and 4 supraclavicular radiculoplexus lesions. Conclusions: The frequency of nerve involvement reflects the motor predilection of NA. Involvement of pure motor nerves exceeded that of predominantly motor nerves, both of which far exceeded involvement of more evenly mixed sensorimotor nerves. Cutaneous sensory nerves were least commonly involved. Because of the common C5–C6 innervation, NA often mimics an upper plexus lesion. Extraplexus nerve involvement far exceeded plexus involvement. Distal motor branch involvement explains the severe single-muscle wasting and weakness often observed. Muscle Nerve 55: 858–861, 2017.",
author = "Mark Ferrante and Wilbourn, {Asa J.}",
year = "2017",
month = "6",
day = "1",
doi = "10.1002/mus.25422",
language = "English (US)",
volume = "55",
pages = "858--861",
journal = "Muscle and Nerve",
issn = "0148-639X",
publisher = "John Wiley and Sons Inc.",
number = "6",

}

TY - JOUR

T1 - Lesion distribution among 281 patients with sporadic neuralgic amyotrophy

AU - Ferrante, Mark

AU - Wilbourn, Asa J.

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Introduction: The muscles commonly affected by neuralgic amyotrophy (NA) are well known, but the location of the responsible lesions is less clear (plexus versus extraplexus). Methods: We report the lesion locations in 281 NA patients as determined by extensive electrodiagnostic (EDX) testing. Results: Our 281 patients had 322 bouts of NA, 57 of which were bilateral, for a total of 379 assessable events. A single nerve was involved in 174 (46%), and 205 (54%) were multifocal. EDX testing identified 703 individual lesions: 699 neuropathies and 4 supraclavicular radiculoplexus lesions. Conclusions: The frequency of nerve involvement reflects the motor predilection of NA. Involvement of pure motor nerves exceeded that of predominantly motor nerves, both of which far exceeded involvement of more evenly mixed sensorimotor nerves. Cutaneous sensory nerves were least commonly involved. Because of the common C5–C6 innervation, NA often mimics an upper plexus lesion. Extraplexus nerve involvement far exceeded plexus involvement. Distal motor branch involvement explains the severe single-muscle wasting and weakness often observed. Muscle Nerve 55: 858–861, 2017.

AB - Introduction: The muscles commonly affected by neuralgic amyotrophy (NA) are well known, but the location of the responsible lesions is less clear (plexus versus extraplexus). Methods: We report the lesion locations in 281 NA patients as determined by extensive electrodiagnostic (EDX) testing. Results: Our 281 patients had 322 bouts of NA, 57 of which were bilateral, for a total of 379 assessable events. A single nerve was involved in 174 (46%), and 205 (54%) were multifocal. EDX testing identified 703 individual lesions: 699 neuropathies and 4 supraclavicular radiculoplexus lesions. Conclusions: The frequency of nerve involvement reflects the motor predilection of NA. Involvement of pure motor nerves exceeded that of predominantly motor nerves, both of which far exceeded involvement of more evenly mixed sensorimotor nerves. Cutaneous sensory nerves were least commonly involved. Because of the common C5–C6 innervation, NA often mimics an upper plexus lesion. Extraplexus nerve involvement far exceeded plexus involvement. Distal motor branch involvement explains the severe single-muscle wasting and weakness often observed. Muscle Nerve 55: 858–861, 2017.

UR - http://www.scopus.com/inward/record.url?scp=85012259307&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85012259307&partnerID=8YFLogxK

U2 - 10.1002/mus.25422

DO - 10.1002/mus.25422

M3 - Article

VL - 55

SP - 858

EP - 861

JO - Muscle and Nerve

JF - Muscle and Nerve

SN - 0148-639X

IS - 6

ER -