Lethal disseminated dysembryoplastic neuroepithelial tumor following West Nile virus

Report of a very unusual combination

Amy Farkas, David Joyner, Ali Saad, Mark Anderson, Majid Khan

Research output: Contribution to journalArticle

Abstract

Dysembryoplastic neuroepithelial tumors (DNETs) are typically benign World Health Organization (WHO) grade I tumors of the cortical or deep gray matter with a favorable prognosis. We encountered a patient with DNET who has been evaluated and treated for West Nile encephalitis 7 months before presentation. Over the course of 2 years, the patient developed diffuse leptomeningeal carcinomatosis. As the disease burden increased, the patient eventually became quadriparetic. The patient elected for hospice care and expired shortly thereafter. Autopsy revealed DNET (WHO grade I) with extensive involvement of the cervical, thoracic, and lumbar spinal cord, bilateral cerebellar hemispheres, brainstem, the cortex of the right frontal and temporal lobes, and meningeal carcinomatosis of the brain and spinal cord. Mortality from DNET is rare, and as per our extensive literature search, there has been only 1 case reported of death attributed to seizures from this diagnosis. To the best of our knowledge, this is the only case of disseminated DNET with meningeal infiltration or carcinomatosis resulting in mortality.

Original languageEnglish (US)
Pages (from-to)555-558
Number of pages4
JournalRadiology Case Reports
Volume13
Issue number3
DOIs
StatePublished - Jun 1 2018

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Neuroepithelial Neoplasms
West Nile virus
Meningeal Carcinomatosis
Spinal Cord
Hospice Care
Mortality
Frontal Lobe
Encephalitis
Temporal Lobe
Brain Stem
Autopsy
Seizures
Thorax
Carcinoma
Brain
Neoplasms

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Lethal disseminated dysembryoplastic neuroepithelial tumor following West Nile virus : Report of a very unusual combination. / Farkas, Amy; Joyner, David; Saad, Ali; Anderson, Mark; Khan, Majid.

In: Radiology Case Reports, Vol. 13, No. 3, 01.06.2018, p. 555-558.

Research output: Contribution to journalArticle

Farkas, Amy ; Joyner, David ; Saad, Ali ; Anderson, Mark ; Khan, Majid. / Lethal disseminated dysembryoplastic neuroepithelial tumor following West Nile virus : Report of a very unusual combination. In: Radiology Case Reports. 2018 ; Vol. 13, No. 3. pp. 555-558.
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