Lidocaine Inactivation of Ventral Subiculum Attenuates Cocaine-Seeking Behavior in Rats

Wen Lin Sun, George V. Rebec

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

The role of the ventral subiculum in cocaine- or cue-induced cocaine-seeking behavior was investigated in rats tested on a between-session reinstatement model. Rats were trained to self-administer cocaine (0.25 mg/infusion, i.v.) in a lever-pressing operant task in a daily 2 hr session. Responding was reinforced contingent on a modified fixed-ratio 5 schedule. Reinstatement tests began after the lever-pressing behavior was extinguished in the absence of cocaine and conditioned cues (light and tone). Bilateral microinjections of lidocaine (100 μg) into the ventral subiculum decreased cocaine- or cue-induced reinstatement of cocaine-seeking behavior compared with saline microinjections into the same area in another group of rats. Lidocaine microinjections, however, had no effect on cocaine self-administration behavior or food-maintained or food-reinstated responding. Collectively, these results suggest that the ventral subiculum plays an important role in cocaine-seeking behavior. Considering the role of this structure in context learning, our data suggest that the full expression of cocaine- or cue-induced reinstatement may depend on the context in which the cocaine experience occurred.

Original languageEnglish (US)
Pages (from-to)10258-10264
Number of pages7
JournalJournal of Neuroscience
Volume23
Issue number32
StatePublished - Nov 12 2003
Externally publishedYes

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Lidocaine
Cocaine
Hippocampus
Cues
Microinjections
Food
Self Administration
Appointments and Schedules
Learning
Light

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Lidocaine Inactivation of Ventral Subiculum Attenuates Cocaine-Seeking Behavior in Rats. / Sun, Wen Lin; Rebec, George V.

In: Journal of Neuroscience, Vol. 23, No. 32, 12.11.2003, p. 10258-10264.

Research output: Contribution to journalArticle

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