Life Expectancy for Patients From the Southeastern United States With IgA Nephropathy

M. Colleen Hastings, Zoran Bursac, Bruce A. Julian, Emanuel Villa Baca, Jennifer Featherston, Susan Y. Woodford, Lisa Bailey, Robert J. Wyatt

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Introduction: Although end-stage renal disease (ESRD) and surrogate markers for renal dysfunction are frequently used as outcome markers for IgA nephropathy, the clinical course after reaching ESRD is not well documented. This study examined outcomes of progression to ESRD and age at death in a cohort of adults with IgA nephropathy with a long duration of follow-up. Methods: Patient and kidney survival of 251 adult patients with IgA nephropathy from the southeastern United States diagnosed between January 1, 1976 and December 31, 2005 were analyzed. Results: Median age at diagnosis was 36.9 years. Most patients were men (69%) and Caucasian (95%). Only 46% had an estimated glomerular filtration rate >60 ml/min per 1.73 m2 at diagnosis. Mean follow-up time from time of diagnostic biopsy to death or end of study was 19.3 years. Of 251 patients, 132 (53%) progressed to ESRD and 97 (39%) died. Life expectancy was reduced by 10.1 years, with a median observed age of death at 65.7 years and a median expected age at death of 75.8 years. Eighty-three percent of the deaths occurred after progression to ESRD. Conclusion: Life expectancy is substantially reduced for patients diagnosed with IgA nephropathy in the southeastern United States.

Original languageEnglish (US)
Pages (from-to)99-104
Number of pages6
JournalKidney International Reports
Volume3
Issue number1
DOIs
StatePublished - Jan 1 2018

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Southeastern United States
Life Expectancy
Immunoglobulin A
Chronic Kidney Failure
Kidney
Glomerular Filtration Rate
Biomarkers
Outcome Assessment (Health Care)
Biopsy

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Hastings, M. C., Bursac, Z., Julian, B. A., Villa Baca, E., Featherston, J., Woodford, S. Y., ... Wyatt, R. J. (2018). Life Expectancy for Patients From the Southeastern United States With IgA Nephropathy. Kidney International Reports, 3(1), 99-104. https://doi.org/10.1016/j.ekir.2017.08.008

Life Expectancy for Patients From the Southeastern United States With IgA Nephropathy. / Hastings, M. Colleen; Bursac, Zoran; Julian, Bruce A.; Villa Baca, Emanuel; Featherston, Jennifer; Woodford, Susan Y.; Bailey, Lisa; Wyatt, Robert J.

In: Kidney International Reports, Vol. 3, No. 1, 01.01.2018, p. 99-104.

Research output: Contribution to journalArticle

Hastings, MC, Bursac, Z, Julian, BA, Villa Baca, E, Featherston, J, Woodford, SY, Bailey, L & Wyatt, RJ 2018, 'Life Expectancy for Patients From the Southeastern United States With IgA Nephropathy', Kidney International Reports, vol. 3, no. 1, pp. 99-104. https://doi.org/10.1016/j.ekir.2017.08.008
Hastings, M. Colleen ; Bursac, Zoran ; Julian, Bruce A. ; Villa Baca, Emanuel ; Featherston, Jennifer ; Woodford, Susan Y. ; Bailey, Lisa ; Wyatt, Robert J. / Life Expectancy for Patients From the Southeastern United States With IgA Nephropathy. In: Kidney International Reports. 2018 ; Vol. 3, No. 1. pp. 99-104.
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