Lifestyle and endometrial cancer risk

A cohort study from the Swedish twin registry

Paul Terry, John A. Baron, Elisabete Weiderpass, Jonathan Yuen, Paul Lichtenstein, Olof Nyrén

Research output: Contribution to journalArticle

139 Citations (Scopus)

Abstract

Case-control studies of lifestyle factors have been inconclusive in the study of endometrial cancer, and prospective data are scarce. Our aim was to examine the associations of physical activity, weight and weight change, fruit, vegetable, and alcohol consumption, socio-economic status, parity and presence of diabetes mellitus with the risk of endometrial cancer in a cohort study. In 1967, 11,659 women in the Swedish Twin Registry, born 1886-1925, answered a 107-item questionnaire, including questions about diet, physical activity and other lifestyle factors. Complete follow-up through 1992 was attained through record linkage to the Swedish Cancer and Death Registers. The relative risks for endometrial cancer were estimated in proportional hazards models that adjusted confidence limits for correlated outcomes. We observed 133 incident cases of endometrial cancer in the cohort. There was no clear pattern of risk over strata of alcohol or fruit and vegetable intake, although the data suggest an increased risk with very low fruit and vegetable intake. Increasing physical activity markedly decreased the risk of endometrial cancer (p for trend < 0.01), independently of weight and parity; the risk in the highest quartile, relative to the sedentary category, was 0.2 (95% CI 0.3-0.8). As expected, higher weight in middle age increased the risk (p for trend < 0.01), as did higher weight in early adulthood. Contrary to previous findings, weight gain did not have an effect independent of weight at enrollment. We did not find a genetic component to endometrial cancer. Our results confirm that environmental factors are the most important, especially physical activity, parity, and weight in young and middle age.

Original languageEnglish (US)
Pages (from-to)38-42
Number of pages5
JournalInternational Journal of Cancer
Volume82
Issue number1
DOIs
StatePublished - Jul 2 1999

Fingerprint

Endometrial Neoplasms
Registries
Life Style
Cohort Studies
Weights and Measures
Parity
Vegetables
Exercise
Fruit
Proportional Hazards Models
Alcohol Drinking
Weight Gain
Case-Control Studies
Diabetes Mellitus
Alcohols
Economics
Diet
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Lifestyle and endometrial cancer risk : A cohort study from the Swedish twin registry. / Terry, Paul; Baron, John A.; Weiderpass, Elisabete; Yuen, Jonathan; Lichtenstein, Paul; Nyrén, Olof.

In: International Journal of Cancer, Vol. 82, No. 1, 02.07.1999, p. 38-42.

Research output: Contribution to journalArticle

Terry, Paul ; Baron, John A. ; Weiderpass, Elisabete ; Yuen, Jonathan ; Lichtenstein, Paul ; Nyrén, Olof. / Lifestyle and endometrial cancer risk : A cohort study from the Swedish twin registry. In: International Journal of Cancer. 1999 ; Vol. 82, No. 1. pp. 38-42.
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