Lifetime number of ovulatory cycles and epithelial ovarian cancer risk in African American women

Lauren C. Peres, Patricia G. Moorman, Anthony J. Alberg, Elisa V. Bandera, Jill Barnholtz-Sloan, Melissa Bondy, Michele L. Cote, Ellen Funkhouser, Edward S. Peters, Ann G. Schwartz, Paul Terry, Sarah E. Abbott, Fabian Camacho, Frances Wang, Joellen M. Schildkraut

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: Incessant ovulation has been consistently linked to epithelial ovarian cancer (EOC). Although reproductive characteristics differ substantially by race, the association between incessant ovulation and EOC has been evaluated only in populations of predominantly white women. In the present study, we examined the association between lifetime number of ovulatory cycles (LOCs) and EOC risk among African American (AA) women. Methods: We used data from 534 cases and 722 controls enrolled in the African American Cancer Epidemiology Study. LOCs were determined using the standard method, with modifications to include episodes of irregular or missed periods. Multivariable logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between LOCs and EOC risk overall and by age, while adjusting for appropriate confounders. Results: The mean number of LOCs was 378.2 ± 105.8 for cases and 346.4 ± 117.3 for controls. Women in the highest tertile of LOCs had 59% higher odds of EOC compared to women in the lowest tertile (OR = 1.59; 95% CI = 1.15–2.20). When examining this relationship by age, the positive association with EOC was stronger among women <50 years of age (OR for highest vs. lowest tertile = 2.61; 95% CI = 1.15–5.94), followed by women aged 50–60 years (OR = 2.27; 95% CI = 1.30–3.94). Yet, no association was present among women aged >60 years (OR = 0.79; 95% CI = 0.45–1.40). Conclusions: In a population of AA women, we observed a positive association between LOCs and EOC risk, providing further support for the hypothesis that incessant ovulation contributes to the etiology of EOC.

Original languageEnglish (US)
Pages (from-to)405-414
Number of pages10
JournalCancer Causes and Control
Volume28
Issue number5
DOIs
StatePublished - May 1 2017

Fingerprint

African Americans
Ovulation
Odds Ratio
Confidence Intervals
Ovarian epithelial cancer
Population
Epidemiology
Logistic Models
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Peres, L. C., Moorman, P. G., Alberg, A. J., Bandera, E. V., Barnholtz-Sloan, J., Bondy, M., ... Schildkraut, J. M. (2017). Lifetime number of ovulatory cycles and epithelial ovarian cancer risk in African American women. Cancer Causes and Control, 28(5), 405-414. https://doi.org/10.1007/s10552-017-0853-7

Lifetime number of ovulatory cycles and epithelial ovarian cancer risk in African American women. / Peres, Lauren C.; Moorman, Patricia G.; Alberg, Anthony J.; Bandera, Elisa V.; Barnholtz-Sloan, Jill; Bondy, Melissa; Cote, Michele L.; Funkhouser, Ellen; Peters, Edward S.; Schwartz, Ann G.; Terry, Paul; Abbott, Sarah E.; Camacho, Fabian; Wang, Frances; Schildkraut, Joellen M.

In: Cancer Causes and Control, Vol. 28, No. 5, 01.05.2017, p. 405-414.

Research output: Contribution to journalArticle

Peres, LC, Moorman, PG, Alberg, AJ, Bandera, EV, Barnholtz-Sloan, J, Bondy, M, Cote, ML, Funkhouser, E, Peters, ES, Schwartz, AG, Terry, P, Abbott, SE, Camacho, F, Wang, F & Schildkraut, JM 2017, 'Lifetime number of ovulatory cycles and epithelial ovarian cancer risk in African American women', Cancer Causes and Control, vol. 28, no. 5, pp. 405-414. https://doi.org/10.1007/s10552-017-0853-7
Peres LC, Moorman PG, Alberg AJ, Bandera EV, Barnholtz-Sloan J, Bondy M et al. Lifetime number of ovulatory cycles and epithelial ovarian cancer risk in African American women. Cancer Causes and Control. 2017 May 1;28(5):405-414. https://doi.org/10.1007/s10552-017-0853-7
Peres, Lauren C. ; Moorman, Patricia G. ; Alberg, Anthony J. ; Bandera, Elisa V. ; Barnholtz-Sloan, Jill ; Bondy, Melissa ; Cote, Michele L. ; Funkhouser, Ellen ; Peters, Edward S. ; Schwartz, Ann G. ; Terry, Paul ; Abbott, Sarah E. ; Camacho, Fabian ; Wang, Frances ; Schildkraut, Joellen M. / Lifetime number of ovulatory cycles and epithelial ovarian cancer risk in African American women. In: Cancer Causes and Control. 2017 ; Vol. 28, No. 5. pp. 405-414.
@article{edd2893b9a4d40f99cb307758a73d092,
title = "Lifetime number of ovulatory cycles and epithelial ovarian cancer risk in African American women",
abstract = "Purpose: Incessant ovulation has been consistently linked to epithelial ovarian cancer (EOC). Although reproductive characteristics differ substantially by race, the association between incessant ovulation and EOC has been evaluated only in populations of predominantly white women. In the present study, we examined the association between lifetime number of ovulatory cycles (LOCs) and EOC risk among African American (AA) women. Methods: We used data from 534 cases and 722 controls enrolled in the African American Cancer Epidemiology Study. LOCs were determined using the standard method, with modifications to include episodes of irregular or missed periods. Multivariable logistic regression was used to estimate odds ratios (ORs) and 95{\%} confidence intervals (CIs) for the association between LOCs and EOC risk overall and by age, while adjusting for appropriate confounders. Results: The mean number of LOCs was 378.2 ± 105.8 for cases and 346.4 ± 117.3 for controls. Women in the highest tertile of LOCs had 59{\%} higher odds of EOC compared to women in the lowest tertile (OR = 1.59; 95{\%} CI = 1.15–2.20). When examining this relationship by age, the positive association with EOC was stronger among women <50 years of age (OR for highest vs. lowest tertile = 2.61; 95{\%} CI = 1.15–5.94), followed by women aged 50–60 years (OR = 2.27; 95{\%} CI = 1.30–3.94). Yet, no association was present among women aged >60 years (OR = 0.79; 95{\%} CI = 0.45–1.40). Conclusions: In a population of AA women, we observed a positive association between LOCs and EOC risk, providing further support for the hypothesis that incessant ovulation contributes to the etiology of EOC.",
author = "Peres, {Lauren C.} and Moorman, {Patricia G.} and Alberg, {Anthony J.} and Bandera, {Elisa V.} and Jill Barnholtz-Sloan and Melissa Bondy and Cote, {Michele L.} and Ellen Funkhouser and Peters, {Edward S.} and Schwartz, {Ann G.} and Paul Terry and Abbott, {Sarah E.} and Fabian Camacho and Frances Wang and Schildkraut, {Joellen M.}",
year = "2017",
month = "5",
day = "1",
doi = "10.1007/s10552-017-0853-7",
language = "English (US)",
volume = "28",
pages = "405--414",
journal = "Cancer Causes and Control",
issn = "0957-5243",
publisher = "Springer Netherlands",
number = "5",

}

TY - JOUR

T1 - Lifetime number of ovulatory cycles and epithelial ovarian cancer risk in African American women

AU - Peres, Lauren C.

AU - Moorman, Patricia G.

AU - Alberg, Anthony J.

AU - Bandera, Elisa V.

AU - Barnholtz-Sloan, Jill

AU - Bondy, Melissa

AU - Cote, Michele L.

AU - Funkhouser, Ellen

AU - Peters, Edward S.

AU - Schwartz, Ann G.

AU - Terry, Paul

AU - Abbott, Sarah E.

AU - Camacho, Fabian

AU - Wang, Frances

AU - Schildkraut, Joellen M.

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Purpose: Incessant ovulation has been consistently linked to epithelial ovarian cancer (EOC). Although reproductive characteristics differ substantially by race, the association between incessant ovulation and EOC has been evaluated only in populations of predominantly white women. In the present study, we examined the association between lifetime number of ovulatory cycles (LOCs) and EOC risk among African American (AA) women. Methods: We used data from 534 cases and 722 controls enrolled in the African American Cancer Epidemiology Study. LOCs were determined using the standard method, with modifications to include episodes of irregular or missed periods. Multivariable logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between LOCs and EOC risk overall and by age, while adjusting for appropriate confounders. Results: The mean number of LOCs was 378.2 ± 105.8 for cases and 346.4 ± 117.3 for controls. Women in the highest tertile of LOCs had 59% higher odds of EOC compared to women in the lowest tertile (OR = 1.59; 95% CI = 1.15–2.20). When examining this relationship by age, the positive association with EOC was stronger among women <50 years of age (OR for highest vs. lowest tertile = 2.61; 95% CI = 1.15–5.94), followed by women aged 50–60 years (OR = 2.27; 95% CI = 1.30–3.94). Yet, no association was present among women aged >60 years (OR = 0.79; 95% CI = 0.45–1.40). Conclusions: In a population of AA women, we observed a positive association between LOCs and EOC risk, providing further support for the hypothesis that incessant ovulation contributes to the etiology of EOC.

AB - Purpose: Incessant ovulation has been consistently linked to epithelial ovarian cancer (EOC). Although reproductive characteristics differ substantially by race, the association between incessant ovulation and EOC has been evaluated only in populations of predominantly white women. In the present study, we examined the association between lifetime number of ovulatory cycles (LOCs) and EOC risk among African American (AA) women. Methods: We used data from 534 cases and 722 controls enrolled in the African American Cancer Epidemiology Study. LOCs were determined using the standard method, with modifications to include episodes of irregular or missed periods. Multivariable logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between LOCs and EOC risk overall and by age, while adjusting for appropriate confounders. Results: The mean number of LOCs was 378.2 ± 105.8 for cases and 346.4 ± 117.3 for controls. Women in the highest tertile of LOCs had 59% higher odds of EOC compared to women in the lowest tertile (OR = 1.59; 95% CI = 1.15–2.20). When examining this relationship by age, the positive association with EOC was stronger among women <50 years of age (OR for highest vs. lowest tertile = 2.61; 95% CI = 1.15–5.94), followed by women aged 50–60 years (OR = 2.27; 95% CI = 1.30–3.94). Yet, no association was present among women aged >60 years (OR = 0.79; 95% CI = 0.45–1.40). Conclusions: In a population of AA women, we observed a positive association between LOCs and EOC risk, providing further support for the hypothesis that incessant ovulation contributes to the etiology of EOC.

UR - http://www.scopus.com/inward/record.url?scp=85014087532&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85014087532&partnerID=8YFLogxK

U2 - 10.1007/s10552-017-0853-7

DO - 10.1007/s10552-017-0853-7

M3 - Article

VL - 28

SP - 405

EP - 414

JO - Cancer Causes and Control

JF - Cancer Causes and Control

SN - 0957-5243

IS - 5

ER -