Light/dye microvascular injury eliminates pial arteriolar dilation in hypotensive piglets

Timothy H. Eidson, Jamie L. Edrington, Maria Luiza C. Albuquerque, Samuel L. Zuckerman, Charles Leffler

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Cerebral vasodilation in response to hypotension is necessary to maintain adequate cerebral blood flow. This study in newborn pigs examines the hypothesis that endothelial injury in vivo inhibits cerebral vasodilation in response to hypotension in newborn pigs, thus suggesting that this response is endothelium dependent. Chloralose-anesthetized piglets with closed cranial windows were studied before and after injury caused by light/dye or before and after dye only sham control. Light/dye injury was produced by injecting sodium fluorescein i.v. and passing filtered light from a mercury arc lamp though the cranial window. Measurements of pial arteries and arterioles were made during normotensive and hypotensive periods. Hemorrhagic hypotension (to 50% of the mean arterial control value) caused pial arterial and arteriolar diameters to increase 49 ± 8% and 66 ± 8%, respectively. After the light/dye injury, dilation in response to hypotension was absent, whereas dilations in response to isoproterenol and constriction in response to hypertension (3.33 to 4.0 kPa increase in arterial pressure) and hypocapnia were retained. These findings are consistent with the hypothesis that hypotension-induced cerebral arteriolar vasodilation is dependent on endothelial signals influencing adjacent smooth muscle.

Original languageEnglish (US)
Pages (from-to)10-14
Number of pages5
JournalPediatric Research
Volume37
Issue number1
DOIs
StatePublished - Jan 1 1995

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Hypotension
Dilatation
Coloring Agents
Vasodilation
Light
Wounds and Injuries
Cerebrovascular Circulation
Swine
Controlled Hypotension
Hypocapnia
Chloralose
Arterioles
Fluorescein
Mercury
Isoproterenol
Constriction
Endothelium
Smooth Muscle
Arterial Pressure
Arteries

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Light/dye microvascular injury eliminates pial arteriolar dilation in hypotensive piglets. / Eidson, Timothy H.; Edrington, Jamie L.; Albuquerque, Maria Luiza C.; Zuckerman, Samuel L.; Leffler, Charles.

In: Pediatric Research, Vol. 37, No. 1, 01.01.1995, p. 10-14.

Research output: Contribution to journalArticle

Eidson, Timothy H. ; Edrington, Jamie L. ; Albuquerque, Maria Luiza C. ; Zuckerman, Samuel L. ; Leffler, Charles. / Light/dye microvascular injury eliminates pial arteriolar dilation in hypotensive piglets. In: Pediatric Research. 1995 ; Vol. 37, No. 1. pp. 10-14.
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