Lineage versus environment in embryonic retina

a revisionist perspective

Robert Williams, Dan Goldowitz

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The idea that microenvironmental cues act alone late in development to determine a cell's phenotype has dominated recent discussion of retinal development, and has successfully displaced the notion of any role for cell lineage in the process of cell determination. We argue that there is, in fact, evidence favoring a degree of lineage restriction during the development of the vertebrate retina. We propose that environmental factors modulate a process of progressive lineage restriction. In this model, progenitor cells are viewed as having unequal potential, and their progeny are viewed as being committed to one of the major retinal cell classes before the stage at which they become postmitotic.

Original languageEnglish (US)
Pages (from-to)368-373
Number of pages6
JournalTrends in neurosciences
Volume15
Issue number10
DOIs
StatePublished - Jan 1 1992

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Retina
Cell Lineage
Cues
Vertebrates
Stem Cells
Phenotype

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Lineage versus environment in embryonic retina : a revisionist perspective. / Williams, Robert; Goldowitz, Dan.

In: Trends in neurosciences, Vol. 15, No. 10, 01.01.1992, p. 368-373.

Research output: Contribution to journalArticle

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