Lipid clearing in premature infants during continuous heparin infusion

Role of circulating lipases

Hada Zaidan, Ramasubbareddy Dhanireddy, Margit Hamosh, Gunilla Bengtsson-Olivecrona, Paul Hamosh

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The nature of the lipases released into the circulation during low level continuous infusion of heparin (1 unit/ml total parenteral nutrition) and after bolus heparin injection (10 units/kg) was investigated in a group of 11 low birth weight infants (gestational age 27–34 wk, and postnatal age of 7–26 days) receiving total parenteral nutrition with Intralipid (0.5 g/kg). Hepatic lipase and extrahepatic lipoprotein lipase were differentiated with the aid of an antibody specific for human hepatic lipase. The data show that continuous low level heparin infusion leads to a constant baseline postheparin lipolytic activity of 0.77 ± 0.18 µmol free fatty acids released per milliliter serum per hour. Bolus heparin injection leads to peak lipolytic activity levels of 3.77 ± 0.46 µmol free fatty acids per milliliter serum per hour, 10 min after injection. About two-thirds of the total postheparin lipolytic activity was of the hepatic type during low level continuous infusion or after bolus injection of heparin.

Original languageEnglish (US)
Pages (from-to)23-25
Number of pages3
JournalPediatric Research
Volume19
Issue number1
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

Fingerprint

Lipase
Premature Infants
Heparin
Lipids
Injections
Total Parenteral Nutrition
Nonesterified Fatty Acids
Lipoprotein Lipase
Liver
Low Birth Weight Infant
Serum
Gestational Age
Antibodies

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Lipid clearing in premature infants during continuous heparin infusion : Role of circulating lipases. / Zaidan, Hada; Dhanireddy, Ramasubbareddy; Hamosh, Margit; Bengtsson-Olivecrona, Gunilla; Hamosh, Paul.

In: Pediatric Research, Vol. 19, No. 1, 01.01.1985, p. 23-25.

Research output: Contribution to journalArticle

Zaidan, Hada ; Dhanireddy, Ramasubbareddy ; Hamosh, Margit ; Bengtsson-Olivecrona, Gunilla ; Hamosh, Paul. / Lipid clearing in premature infants during continuous heparin infusion : Role of circulating lipases. In: Pediatric Research. 1985 ; Vol. 19, No. 1. pp. 23-25.
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