Lipocortin-1 immunoreactivity in central and peripheral nervous system glial tumors

Mahlon Johnson, Jimmy Kamso-Pratt, R. Blake Pepinsky, William O. Whetsell

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

We examined the cellular distribution of lipocortin-1 (L-1), a major physiologic substrate for the epidermal growth factor receptor/kinase, in 122 central nervous system (CNS) and peripheral nervous system (PNS) neoplasms using the peroxidase-antiperoxidase technique with a polyclonal antibody specific for L-1. Extensive L-1 immunoreactivity was demonstrated in many CNS tumors; in 11 of 21 glioblastoma multiformes, in five of 12 anaplastic astrocytomas, and in five of 14 astrocytomas. Significant numbers of immunoreactive ependymocytes or astrocytes were also seen in six of 13 ependymomas. In contrast, no immunostaining was detected in the oligodendrocytes in any of ten oligodendrogliomas. PNS tumors, found in two of five malignant nerve sheath tumors, 13 of 15 schwannomas, 13 of 17 neurofibromas, and 14 of 15 traumatic neuromas, also contained considerable L-1 immunoreactivity in Schwann cells or mast cells. These findings raise the possibility that L-1 may participate in the proliferation or subsequent differentiation of neoplastic astrocytes, ependymocytes, and Schwann cells.

Original languageEnglish (US)
Pages (from-to)772-776
Number of pages5
JournalHuman Pathology
Volume20
Issue number8
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

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Annexin A1
Nervous System Neoplasms
Schwann Cells
Astrocytoma
Peripheral Nervous System
Neuroglia
Astrocytes
Peripheral Nervous System Neoplasms
Central Nervous System
Nerve Sheath Neoplasms
Oligodendroglioma
Neuroma
Ependymoma
Neurofibroma
Central Nervous System Neoplasms
Neurilemmoma
Oligodendroglia
Glioblastoma
Epidermal Growth Factor Receptor
Mast Cells

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Lipocortin-1 immunoreactivity in central and peripheral nervous system glial tumors. / Johnson, Mahlon; Kamso-Pratt, Jimmy; Blake Pepinsky, R.; Whetsell, William O.

In: Human Pathology, Vol. 20, No. 8, 01.01.1989, p. 772-776.

Research output: Contribution to journalArticle

Johnson, Mahlon ; Kamso-Pratt, Jimmy ; Blake Pepinsky, R. ; Whetsell, William O. / Lipocortin-1 immunoreactivity in central and peripheral nervous system glial tumors. In: Human Pathology. 1989 ; Vol. 20, No. 8. pp. 772-776.
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