Liposomal drug delivery system

Kazuo Maruyama, Stephen Kennel, Leaf Huang

Research output: Contribution to journalConference article

1 Citation (Scopus)

Abstract

We have recently described an immunoliposome targeting system which involves the use of monoclonal antibodies specific for the pulmonary endothelial cells. We have employed the antibodies, 34A and 201B, which bind to a surface glycoprotein, gp112, which is specifically expressed in high concentrations in the capillary endothelial cells of the mouse lung. Intravenously injected immunoliposomes (34A- or 201B-liposomes) to the mice gain direct access and bind efficiently to the lung. Approximately 50% of the injected dose was accumulated in the lung for 34A-liposomes which contained an average of 935 antibody molecules per liposome. Lung accumulation of 34A-liposomes is completely blocked by a preinjection of free antibody 34A, indicating that the immunoliposome accumulation at the target site is immunospecific. The level of lung accumulation increases significantly as the antibody/lipid ratio of the immunoliposome increases.

Original languageEnglish (US)
Pages (from-to)159-160
Number of pages2
JournalAmerican Chemical Society, Polymer Preprints, Division of Polymer Chemistry
Volume31
Issue number2
StatePublished - Aug 1 1990
Externally publishedYes
EventPapers presented at the Washington, DC Meeting 1990 of the ACS, Division of Polymer Chemistry - Washington, DC, USA
Duration: Aug 26 1990Aug 31 1990

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Liposomes
Antibodies
Endothelial cells
Glycoproteins
Monoclonal antibodies
Membrane Glycoproteins
Lipids
Monoclonal Antibodies
Molecules
Drug Delivery Systems

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Polymers and Plastics
  • Engineering(all)

Cite this

Liposomal drug delivery system. / Maruyama, Kazuo; Kennel, Stephen; Huang, Leaf.

In: American Chemical Society, Polymer Preprints, Division of Polymer Chemistry, Vol. 31, No. 2, 01.08.1990, p. 159-160.

Research output: Contribution to journalConference article

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