Liquid Sucrose Consumption Promotes Obesity and Impairs Glucose Tolerance Without Altering Circulating Insulin Levels

Susan J. Burke, Heidi M. Batdorf, Thomas M. Martin, David H. Burk, Robert C. Noland, Christopher R. Cooley, Michael Karlstad, William D. Johnson, J. Jason Collier

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: Multiple factors contribute to the rising rates of obesity and to difficulties in weight reduction that exist in the worldwide population. Caloric intake via sugar-sweetened beverages may be influential. This study tested the hypothesis that liquid sucrose intake promotes obesity by increasing serum insulin levels and tissue lipid accumulation. Methods: C57BL/6J mice were given 30% sucrose in liquid form. Changes in weight gain, body composition, energy expenditure (EE), and tissue lipid content were measured. Results: Mice drinking sucrose gained more total body mass (TBM), had greater fat mass, and displayed impaired glucose tolerance relative to control mice. These metabolic changes occurred without alterations in circulating insulin levels and despite increases in whole body EE. Lipid accrued in liver, but not skeletal muscle, of sucrose-consuming mice. Oxygen consumption (VO2) correlated with fat-free mass and moderately with TBM, but not with fat mass. ANCOVA for treatment effects on EE, with TBM, VO2, lean body mass, and fat-free mass taken as potential covariates for EE, revealed VO2 as the most significant correlation. Conclusions: Weight gain induced by intake of liquid sucrose in mice is associated with lipid accrual in liver, but not skeletal muscle, and occurs without an increase in circulating insulin.

Original languageEnglish (US)
Pages (from-to)1188-1196
Number of pages9
JournalObesity
Volume26
Issue number7
DOIs
StatePublished - Jul 1 2018

Fingerprint

Sucrose
Obesity
Energy Metabolism
Insulin
Glucose
Fats
Lipids
Weight Gain
Skeletal Muscle
Glucose Intolerance
Liver
Beverages
Body Composition
Energy Intake
Inbred C57BL Mouse
Oxygen Consumption
Drinking
Weight Loss
Serum
Population

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Burke, S. J., Batdorf, H. M., Martin, T. M., Burk, D. H., Noland, R. C., Cooley, C. R., ... Collier, J. J. (2018). Liquid Sucrose Consumption Promotes Obesity and Impairs Glucose Tolerance Without Altering Circulating Insulin Levels. Obesity, 26(7), 1188-1196. https://doi.org/10.1002/oby.22217

Liquid Sucrose Consumption Promotes Obesity and Impairs Glucose Tolerance Without Altering Circulating Insulin Levels. / Burke, Susan J.; Batdorf, Heidi M.; Martin, Thomas M.; Burk, David H.; Noland, Robert C.; Cooley, Christopher R.; Karlstad, Michael; Johnson, William D.; Collier, J. Jason.

In: Obesity, Vol. 26, No. 7, 01.07.2018, p. 1188-1196.

Research output: Contribution to journalArticle

Burke, SJ, Batdorf, HM, Martin, TM, Burk, DH, Noland, RC, Cooley, CR, Karlstad, M, Johnson, WD & Collier, JJ 2018, 'Liquid Sucrose Consumption Promotes Obesity and Impairs Glucose Tolerance Without Altering Circulating Insulin Levels', Obesity, vol. 26, no. 7, pp. 1188-1196. https://doi.org/10.1002/oby.22217
Burke, Susan J. ; Batdorf, Heidi M. ; Martin, Thomas M. ; Burk, David H. ; Noland, Robert C. ; Cooley, Christopher R. ; Karlstad, Michael ; Johnson, William D. ; Collier, J. Jason. / Liquid Sucrose Consumption Promotes Obesity and Impairs Glucose Tolerance Without Altering Circulating Insulin Levels. In: Obesity. 2018 ; Vol. 26, No. 7. pp. 1188-1196.
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