Lntra-A10 injection of H7 blocks the development of sensitization to cocaine

Research output: Contribution to journalArticle

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Abstract

The role of protein kinase activity in the development of behavioral sensitization was examined by injecting the protein kinase inhibitor H7 into the A10 dopamine region 5 min before each of four daily peripheral injections of cocaine. Animals then received a challenge injection of cocaine 24 h after the daily treatments. Intra-AlO injection of H7 attenuated the acute motor-stimulant response to cocaine. Daily injections of H7 prevented the development of an enhanced motor-stimulant response, which occurred with daily cocaine injections, such that the animals’ behavioral response was similar to that of animals receiving their first cocaine injection. These data suggest that increased protein kinase activity in the A10 dopamine region may be important in the development of behavioral sensitization to cocaine.

Original languageEnglish (US)
Pages (from-to)69-72
Number of pages4
JournalNeuroReport
Volume6
Issue number1
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

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antineoplaston A10
Cocaine
Injections
Protein Kinases
Dopamine
Protein Kinase Inhibitors

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Lntra-A10 injection of H7 blocks the development of sensitization to cocaine. / Steketee, Jeffery.

In: NeuroReport, Vol. 6, No. 1, 01.01.1994, p. 69-72.

Research output: Contribution to journalArticle

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