Local regulation of extracellular matrix structure

Karl Weber, Yao Sun, L. C. Katwa

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

The extracellular matrix (ECM) is composed of various collagens, glycosaminoglycans, and elastin bathed by a tissue fluid found throughout the interstitial space. It is this substratum in which fibroblasts and macrophages normally reside, where fibroblast phenotypic transformation occurs, and into which inflammatory cells migrate when called upon during tissue repair. Many diseases, expressed in an organ-specific manner, require organ-specific ECM remodeling. Regulation of fibrillary type I collagen synthesis, whose disproportionate (relative to degradation) accumulation is characteristic of the tissue fibrosis that adversely alters organ function, is therefore of considerable importance. Emerging evidence implicates angiotensin converting enzyme (ACE), found in fibroblast-like cells, and ACE-related peptides, angiotensin II and bradykinin, in serving important regulatory functions that influence wound healing and thereby ECM structure in health and disease. The heart and its collagen matrix have been targeted for discussion in this brief review.

Original languageEnglish (US)
Pages (from-to)81-88
Number of pages8
JournalHerz
Volume20
Issue number2
StatePublished - 1995
Externally publishedYes

Fingerprint

Extracellular Matrix
Fibroblasts
Peptidyl-Dipeptidase A
Collagen
Elastin
Bradykinin
Collagen Type I
Glycosaminoglycans
Angiotensin II
Wound Healing
Fibrosis
Macrophages
Peptides
Health

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Local regulation of extracellular matrix structure. / Weber, Karl; Sun, Yao; Katwa, L. C.

In: Herz, Vol. 20, No. 2, 1995, p. 81-88.

Research output: Contribution to journalReview article

Weber, K, Sun, Y & Katwa, LC 1995, 'Local regulation of extracellular matrix structure', Herz, vol. 20, no. 2, pp. 81-88.
Weber, Karl ; Sun, Yao ; Katwa, L. C. / Local regulation of extracellular matrix structure. In: Herz. 1995 ; Vol. 20, No. 2. pp. 81-88.
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