Local therapies to heal the penis

Fact or fiction?

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Penile rehabilitation has been an area of intense study and debate over the last decade. Interest in this topic was stimulated by the observation that erectile dysfunction remained a significant problem after radical prostatectomy despite meticulous nerve-sparing technique. Smooth muscle alterations and fibrotic changes in the penis were identified as the underlying causes of penile atrophy, veno-occlusive dysfunction, and Peyronie's-like changes that were observed after surgery. Initial observations that intracavernous injection therapies used on a regular basis postoperatively resulted in improvements in the return of spontaneous erectile function led to the development of penile rehabilitation protocols. Chronic dosing of oral type V phosphodiesterase inhibitors is now commonly used by urologists after radical prostatectomy despite a lack of convincing evidence from randomized, placebo-controlled clinical trials. Use of local therapies to heal the penis may have applications beyond the postprostatectomy patient. This article reviews the current evidence behind penile rehabilitation therapy.

Original languageEnglish (US)
Pages (from-to)384-390
Number of pages7
JournalJournal of Andrology
Volume30
Issue number4
DOIs
StatePublished - Jul 1 2009

Fingerprint

Penis
Rehabilitation
Prostatectomy
Phosphodiesterase Inhibitors
Erectile Dysfunction
Atrophy
Smooth Muscle
Therapeutics
Randomized Controlled Trials
Placebos
Injections

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Reproductive Medicine
  • Endocrinology
  • Urology

Cite this

Local therapies to heal the penis : Fact or fiction? / Kim, Edward.

In: Journal of Andrology, Vol. 30, No. 4, 01.07.2009, p. 384-390.

Research output: Contribution to journalArticle

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