Localization of basement membrane components in mucous membrane pemphigoid

J. R. Meyer, Cesar Migliorati, T. E. Daniels, J. S. Greenspan

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We examined the distribution of laminin, type IV collagen, and fibronectin in subepithelial vesicles of oral mucous membrane pemphigoid (MMP). Indirect immunofluorescence staining of these macromolecules was performed on 10 frozen biopsy specimens of oral MMP. We found type IV collagen in the connective tissue floor and laminin in the epithelial roof of these lesions. Our results suggest that the inflammatory injury in oral MMP may disrupt the interaction of laminin with type IV collagen in the basement membrane zone.

Original languageEnglish (US)
Pages (from-to)105-107
Number of pages3
JournalJournal of Investigative Dermatology
Volume84
Issue number2
DOIs
StatePublished - Jan 1 1985

Fingerprint

Bullous Pemphigoid
Collagen Type IV
Laminin
Basement Membrane
Mucous Membrane
Biopsy
Indirect Fluorescent Antibody Technique
Macromolecules
Fibronectins
Connective Tissue
Roofs
Tissue
Staining and Labeling
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Cite this

Localization of basement membrane components in mucous membrane pemphigoid. / Meyer, J. R.; Migliorati, Cesar; Daniels, T. E.; Greenspan, J. S.

In: Journal of Investigative Dermatology, Vol. 84, No. 2, 01.01.1985, p. 105-107.

Research output: Contribution to journalArticle

Meyer, J. R. ; Migliorati, Cesar ; Daniels, T. E. ; Greenspan, J. S. / Localization of basement membrane components in mucous membrane pemphigoid. In: Journal of Investigative Dermatology. 1985 ; Vol. 84, No. 2. pp. 105-107.
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