Localization of ictal and interictal bursting epileptogenic activity in focal cortical dysplasia

Agreement of magnetoencephalography and electrocorticography

H. Ishibashi, P. G. Simos, James Wheless, J. E. Baumgartner, H. L. Kim, E. M. Castillo, R. N. Davis, Andrew Papanicolaou

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Focal cortical dysplasia (FCD) is often associated with severe partial epilepsy. In such cases, interictal frequent rhythmic bursting epileptiform activity (FBREA) on both scalp electroencephalography (EEG) and electrocorticography (ECoG) is generally accepted to be identical to the ictal epileptiform activity. We used magnetoencephalography (or Magnetic Source Imaging (MSI)) to determine the epileptogenic zone in a 6-year-old patient with histopathologically proven FCD and normal magnetic resonance imaging (MRI). MSI was used to localize the sources of both ictal activity and FRBEA, which was then compared with ECoG findings. The intracranial sources of both types of activity co-localized in the left inferior frontal and superior temporal gyri. The location and extent of the epileptogenic area determined by MSI was essentially identical to that determined directly through extra-operative ECoG. In the absence of structural abnormalities detectable on MRI, the noninvasive method of MSI provided valuable information regarding the location and extent of the primary epileptogenic area. This was critical for pre-surgical planning regarding placement of intracranial electrodes and for risk-benefit evaluation.

Original languageEnglish (US)
Pages (from-to)525-530
Number of pages6
JournalNeurological Research
Volume24
Issue number6
DOIs
StatePublished - Sep 1 2002

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Malformations of Cortical Development
Magnetoencephalography
Stroke
Magnetic Resonance Imaging
Partial Epilepsy
Temporal Lobe
Scalp
Electroencephalography
Electrodes
Electrocorticography

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Localization of ictal and interictal bursting epileptogenic activity in focal cortical dysplasia : Agreement of magnetoencephalography and electrocorticography. / Ishibashi, H.; Simos, P. G.; Wheless, James; Baumgartner, J. E.; Kim, H. L.; Castillo, E. M.; Davis, R. N.; Papanicolaou, Andrew.

In: Neurological Research, Vol. 24, No. 6, 01.09.2002, p. 525-530.

Research output: Contribution to journalArticle

Ishibashi, H. ; Simos, P. G. ; Wheless, James ; Baumgartner, J. E. ; Kim, H. L. ; Castillo, E. M. ; Davis, R. N. ; Papanicolaou, Andrew. / Localization of ictal and interictal bursting epileptogenic activity in focal cortical dysplasia : Agreement of magnetoencephalography and electrocorticography. In: Neurological Research. 2002 ; Vol. 24, No. 6. pp. 525-530.
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