Localization of language-specific cortex by using magnetic source imaging and electrical stimulation mapping

Panagiotis G. Simos, Andrew C. Papanicolaou, Joshua I. Breier, James Wheless, Jules E.C. Constantinou, William B. Gormley, William W. Maggio

Research output: Contribution to journalArticle

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Abstract

Object. In this paper the authors demonstrate the concordance between magnetic source (MS) imaging and direct cortical stimulation for mapping receptive language cortex. Methods. In 13 consecutive surgical patients, cortex specialized for receptive language functions was identified noninvasively by obtaining activation maps aided by MS imaging in the context of visual and auditory word-recognition tasks. Surgery was then performed for treatment of medically intractable seizure disorder (eight patients), and for resection of tumor (four), or angioma (one). Mapping of language areas with cortical stimulation was performed intraoperatively in 10 patients and extraoperatively in three. Cortical stimulation mapping verified the accuracy of the MS imaging-based localization in all cases. Conclusions. Information provided by MS imaging can be especially helpful in cases of atypical language representation, including bihemispheric representation, and location of language in areas other than those expected within the dominant hemisphere, such as the anterior portion of the superior temporal gyrus, the posteroinferior portion of the middle temporal gyrus, the basal temporal cortex, and the lateral temporooccipital cortex.

Original languageEnglish (US)
Pages (from-to)787-796
Number of pages10
JournalJournal of Neurosurgery
Volume91
Issue number5
DOIs
StatePublished - Jan 1 1999

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Electric Stimulation
Language
Temporal Lobe
Hemangioma
Epilepsy
Neoplasms
Therapeutics

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

Cite this

Simos, P. G., Papanicolaou, A. C., Breier, J. I., Wheless, J., Constantinou, J. E. C., Gormley, W. B., & Maggio, W. W. (1999). Localization of language-specific cortex by using magnetic source imaging and electrical stimulation mapping. Journal of Neurosurgery, 91(5), 787-796. https://doi.org/10.3171/jns.1999.91.5.0787

Localization of language-specific cortex by using magnetic source imaging and electrical stimulation mapping. / Simos, Panagiotis G.; Papanicolaou, Andrew C.; Breier, Joshua I.; Wheless, James; Constantinou, Jules E.C.; Gormley, William B.; Maggio, William W.

In: Journal of Neurosurgery, Vol. 91, No. 5, 01.01.1999, p. 787-796.

Research output: Contribution to journalArticle

Simos, PG, Papanicolaou, AC, Breier, JI, Wheless, J, Constantinou, JEC, Gormley, WB & Maggio, WW 1999, 'Localization of language-specific cortex by using magnetic source imaging and electrical stimulation mapping', Journal of Neurosurgery, vol. 91, no. 5, pp. 787-796. https://doi.org/10.3171/jns.1999.91.5.0787
Simos, Panagiotis G. ; Papanicolaou, Andrew C. ; Breier, Joshua I. ; Wheless, James ; Constantinou, Jules E.C. ; Gormley, William B. ; Maggio, William W. / Localization of language-specific cortex by using magnetic source imaging and electrical stimulation mapping. In: Journal of Neurosurgery. 1999 ; Vol. 91, No. 5. pp. 787-796.
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