Locomotor and pyretic effects of MDMA-ethanol associations in rats

Jean Christophe Cassel, Hélène Jeltsch, Julie Koenig, Byron Jones

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

3,4-Methylenedioxymethamphetamine [(MDMA) or ecstasy] is a popular club drug often used in combination with ethanol. In the current study, we investigated the effects of MDMA and ethanol combinations on locomotor activity and body temperature of rats. For four consecutive days, male Long-Evans rats were treated daily with a 10-mg/kg dose of MDMA with or without a 1.5-g/kg dose of ethanol. 3,4-Methylenedioxymethamphetamine increased spontaneous activity (on average +1,140%), and this increase was potentiated by ethanol on all days (on average +1,710%). Moreover, ethanol inhibited the MDMA-induced hyperthermia (on average -1.3°C) by the first day of treatment, but not on subsequent treatment days, supporting the suggestion that this effect may undergo tolerance. These observations seem to indicate that combined ethanol-MDMA may induce effects on locomotor activity and thermoregulation that involve separate mechanisms, the first one being less sensitive to tolerance than the second one might be. Results of our study have important implications for understanding the motivation and the health risks of polydrug abusers combining ecstasy and ethanol.

Original languageEnglish (US)
Pages (from-to)285-289
Number of pages5
JournalAlcohol
Volume34
Issue number2-3
DOIs
StatePublished - Jan 1 2004
Externally publishedYes

Fingerprint

N-Methyl-3,4-methylenedioxyamphetamine
Rats
Fever
Ethanol
tolerance
club
health risk
Locomotion
drug
Long Evans Rats
Induced Hyperthermia
Body Temperature Regulation
Health risks
Body Temperature
Health
Therapeutics
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Health(social science)
  • Biochemistry
  • Toxicology
  • Neurology
  • Behavioral Neuroscience

Cite this

Locomotor and pyretic effects of MDMA-ethanol associations in rats. / Cassel, Jean Christophe; Jeltsch, Hélène; Koenig, Julie; Jones, Byron.

In: Alcohol, Vol. 34, No. 2-3, 01.01.2004, p. 285-289.

Research output: Contribution to journalArticle

Cassel, Jean Christophe ; Jeltsch, Hélène ; Koenig, Julie ; Jones, Byron. / Locomotor and pyretic effects of MDMA-ethanol associations in rats. In: Alcohol. 2004 ; Vol. 34, No. 2-3. pp. 285-289.
@article{c7336a33bcf44e19b905f665d244891f,
title = "Locomotor and pyretic effects of MDMA-ethanol associations in rats",
abstract = "3,4-Methylenedioxymethamphetamine [(MDMA) or ecstasy] is a popular club drug often used in combination with ethanol. In the current study, we investigated the effects of MDMA and ethanol combinations on locomotor activity and body temperature of rats. For four consecutive days, male Long-Evans rats were treated daily with a 10-mg/kg dose of MDMA with or without a 1.5-g/kg dose of ethanol. 3,4-Methylenedioxymethamphetamine increased spontaneous activity (on average +1,140{\%}), and this increase was potentiated by ethanol on all days (on average +1,710{\%}). Moreover, ethanol inhibited the MDMA-induced hyperthermia (on average -1.3°C) by the first day of treatment, but not on subsequent treatment days, supporting the suggestion that this effect may undergo tolerance. These observations seem to indicate that combined ethanol-MDMA may induce effects on locomotor activity and thermoregulation that involve separate mechanisms, the first one being less sensitive to tolerance than the second one might be. Results of our study have important implications for understanding the motivation and the health risks of polydrug abusers combining ecstasy and ethanol.",
author = "Cassel, {Jean Christophe} and H{\'e}l{\`e}ne Jeltsch and Julie Koenig and Byron Jones",
year = "2004",
month = "1",
day = "1",
doi = "10.1016/j.alcohol.2004.09.003",
language = "English (US)",
volume = "34",
pages = "285--289",
journal = "Alcohol",
issn = "0741-8329",
publisher = "Elsevier Inc.",
number = "2-3",

}

TY - JOUR

T1 - Locomotor and pyretic effects of MDMA-ethanol associations in rats

AU - Cassel, Jean Christophe

AU - Jeltsch, Hélène

AU - Koenig, Julie

AU - Jones, Byron

PY - 2004/1/1

Y1 - 2004/1/1

N2 - 3,4-Methylenedioxymethamphetamine [(MDMA) or ecstasy] is a popular club drug often used in combination with ethanol. In the current study, we investigated the effects of MDMA and ethanol combinations on locomotor activity and body temperature of rats. For four consecutive days, male Long-Evans rats were treated daily with a 10-mg/kg dose of MDMA with or without a 1.5-g/kg dose of ethanol. 3,4-Methylenedioxymethamphetamine increased spontaneous activity (on average +1,140%), and this increase was potentiated by ethanol on all days (on average +1,710%). Moreover, ethanol inhibited the MDMA-induced hyperthermia (on average -1.3°C) by the first day of treatment, but not on subsequent treatment days, supporting the suggestion that this effect may undergo tolerance. These observations seem to indicate that combined ethanol-MDMA may induce effects on locomotor activity and thermoregulation that involve separate mechanisms, the first one being less sensitive to tolerance than the second one might be. Results of our study have important implications for understanding the motivation and the health risks of polydrug abusers combining ecstasy and ethanol.

AB - 3,4-Methylenedioxymethamphetamine [(MDMA) or ecstasy] is a popular club drug often used in combination with ethanol. In the current study, we investigated the effects of MDMA and ethanol combinations on locomotor activity and body temperature of rats. For four consecutive days, male Long-Evans rats were treated daily with a 10-mg/kg dose of MDMA with or without a 1.5-g/kg dose of ethanol. 3,4-Methylenedioxymethamphetamine increased spontaneous activity (on average +1,140%), and this increase was potentiated by ethanol on all days (on average +1,710%). Moreover, ethanol inhibited the MDMA-induced hyperthermia (on average -1.3°C) by the first day of treatment, but not on subsequent treatment days, supporting the suggestion that this effect may undergo tolerance. These observations seem to indicate that combined ethanol-MDMA may induce effects on locomotor activity and thermoregulation that involve separate mechanisms, the first one being less sensitive to tolerance than the second one might be. Results of our study have important implications for understanding the motivation and the health risks of polydrug abusers combining ecstasy and ethanol.

UR - http://www.scopus.com/inward/record.url?scp=14344257717&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=14344257717&partnerID=8YFLogxK

U2 - 10.1016/j.alcohol.2004.09.003

DO - 10.1016/j.alcohol.2004.09.003

M3 - Article

VL - 34

SP - 285

EP - 289

JO - Alcohol

JF - Alcohol

SN - 0741-8329

IS - 2-3

ER -