Lomofungin inhibition of allophanate hydrolase synthesis in Saccharomyces cerevisiae

Robert P. Lawther, Stephen L. Phillips, Terrance Cooper

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The RNA polymerase inhibitor, lomofungin has been used to determine the half life of specific synthetic capacities (invertase and α-glucosidase) as well as that for gross protein synthesis. In both cases the studies conclude that cognate messenger RNAs decay with a half life of approximately 20 minutes. This antibiotic has been used to determine the half life of allophanate hydrolase specific synthetic capacity. We find that it decays with a half life of about three minutes; a value that agrees with the decay rates of allophanate hydrolase synthetic capacity following removal of inducer. These observations argue that mRNA may be metabolized by two separate routes in Saccharomyces.

Original languageEnglish (US)
Pages (from-to)89-99
Number of pages11
JournalMGG Molecular & General Genetics
Volume137
Issue number2
DOIs
StatePublished - Jun 1 1975
Externally publishedYes

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Allophanate Hydrolase
Half-Life
Saccharomyces cerevisiae
Glucosidases
beta-Fructofuranosidase
Messenger RNA
Saccharomyces
RNA Stability
DNA-Directed RNA Polymerases
Anti-Bacterial Agents
lomofungin
Proteins

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Lomofungin inhibition of allophanate hydrolase synthesis in Saccharomyces cerevisiae. / Lawther, Robert P.; Phillips, Stephen L.; Cooper, Terrance.

In: MGG Molecular & General Genetics, Vol. 137, No. 2, 01.06.1975, p. 89-99.

Research output: Contribution to journalArticle

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