Long-acting injectable hormonal dosage forms for contraception

Linfeng Wu, Dileep R. Janagam, Timothy D. Mandrell, James R. Johnson, Tao Lowe

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Although great efforts have been made to develop long-acting injectable hormonal contraceptives for more than four decades, few long-acting injectable contraceptives have reached the pharmaceutical market or even entered clinical trials. On the other hand, in clinical practice there is an urgent need for injectable long-acting reversible contraceptives which can provide contraceptive protection for more than 3 months after one single injection. Availability of such products will offer great flexibility to women and resolve certain continuation issues currently occurring in clinics. Herein, we reviewed the strategies exploited in the past to develop injectable hormonal contraceptive dosages including drug microcrystal suspensions, drug-loaded microsphere suspensions and in situ forming depot systems for long-term contraception and discussed the potential solutions for remaining issues met in the previous development.

Original languageEnglish (US)
Pages (from-to)2180-2191
Number of pages12
JournalPharmaceutical Research
Volume32
Issue number7
DOIs
StatePublished - Jul 30 2015

Fingerprint

Dosage Forms
Contraceptive Agents
Contraception
Injections
Suspensions
Drug dosage
Pharmaceutical Preparations
Microcrystals
Microspheres
Clinical Trials
Availability

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry
  • Pharmacology (medical)

Cite this

Long-acting injectable hormonal dosage forms for contraception. / Wu, Linfeng; Janagam, Dileep R.; Mandrell, Timothy D.; Johnson, James R.; Lowe, Tao.

In: Pharmaceutical Research, Vol. 32, No. 7, 30.07.2015, p. 2180-2191.

Research output: Contribution to journalReview article

Wu, Linfeng ; Janagam, Dileep R. ; Mandrell, Timothy D. ; Johnson, James R. ; Lowe, Tao. / Long-acting injectable hormonal dosage forms for contraception. In: Pharmaceutical Research. 2015 ; Vol. 32, No. 7. pp. 2180-2191.
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