Long-chain (n-3) fatty acid intake and risk of cancers of the breast and the prostate: Recent epidemiological studies, biological mechanisms, and directions for future research

Paul Terry, Jennifer B. Terry, Thomas E. Rohan

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

The association between dietary (n-3) fatty acids and hormone-responsive cancers continues to attract considerable attention in epidemiological, clinical, and experimental studies. We previously reviewed the epidemiological literature on the association between hormone-responsive cancers and the long-chain fatty acids eicosapentaenoic acid and docosahexaenoic acid. We concluded that the compelling evidence from ecological studies, animal models, and mechanistic experiments in vitro was not supported clearly by the available epidemiological data. To various degrees, epidemiological studies published more recently attempted to address some of the methodological limitations plaguing earlier studies by using validated questionnaires, examining specific fatty acids and their interrelationships, and adjusting estimates for a wider range of potentially confounding factors than in previous studies. In this review, our aim was to update the previous review with the results of recent epidemiological studies and to discuss possible biological mechanisms and directions for future research.

Original languageEnglish (US)
JournalJournal of Nutrition
Volume134
Issue number12 SUPPL.
StatePublished - Dec 2004
Externally publishedYes

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Omega-3 Fatty Acids
long chain fatty acids
omega-3 fatty acids
breast neoplasms
epidemiological studies
Epidemiologic Studies
Prostatic Neoplasms
Fatty Acids
hormones
Hormones
Breast Neoplasms
neoplasms
Eicosapentaenoic Acid
Docosahexaenoic Acids
eicosapentaenoic acid
docosahexaenoic acid
Neoplasms
questionnaires
Animal Models
animal models

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Food Science

Cite this

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