Long-term enhancement of REM sleep following cholinergic stimulation

Subimal Datta, José M. Calvo, James J. Quattrochi, J. Allan Hobson

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

A six day long increase in rapid eye movement (REM) sleep followed the unilateral microinjection of a single dose of the cholinergic agonist drug carbachol into the brain stem of cats. Effective drug injection sites were localized to the pontine peribrachial region containing cholinergic choline acetyltransferase (ChAT) labeled neurons. At the peak of the effect, which occurred 24-28 h post-injection, the relative amount of time devoted to REM sleep tripled, resulting in an absolute time increase from 3.12 to 11.28 h REM sleep per day. This pronounced and prolonged REM sleep increase was associated with marked enhancement of ponto-geniculo-occipital (PGO) waves and with PGO burst cell activity unilateral to the site of injection.

Original languageEnglish (US)
Pages (from-to)619-622
Number of pages4
JournalNeuroReport
Volume2
Issue number10
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

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REM Sleep
Cholinergic Agents
Sleep
Injections
Cholinergic Agonists
Choline O-Acetyltransferase
Microinjections
Carbachol
Brain Stem
Cats
Neurons
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Long-term enhancement of REM sleep following cholinergic stimulation. / Datta, Subimal; Calvo, José M.; Quattrochi, James J.; Hobson, J. Allan.

In: NeuroReport, Vol. 2, No. 10, 01.01.1991, p. 619-622.

Research output: Contribution to journalArticle

Datta, Subimal ; Calvo, José M. ; Quattrochi, James J. ; Hobson, J. Allan. / Long-term enhancement of REM sleep following cholinergic stimulation. In: NeuroReport. 1991 ; Vol. 2, No. 10. pp. 619-622.
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