Long-Term Radiotherapy Outcomes for Nasal Cavity and Septal Cancers

Matthew W. Allen, David Schwartz, Vishal Rana, Pranshanth Adapala, William H. Morrison, Ehab Y. Hanna, Randal S. Weber, Adam S. Garden, K. Kian Ang

Research output: Contribution to journalArticle

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Abstract

Purpose: Carcinoma of the nasal cavity and septum has historically been associated with a poor prognosis. This report updates the long-term outcomes for radiotherapy (RT) of this disease site at the University of Texas M.D. Anderson Cancer Center. Methods and Materials: A retrospective analysis was performed on the data from 68 patients diagnosed with histologically proven carcinoma of the nasal cavity or septum treated with RT for curative intent between 1969 and 2000. The disease histologic type was as follows: 45 (66%) had squamous cell carcinoma, 12 (18%) had adenoid cystic carcinoma, 8 (12%) had adenocarcinoma, and 3 (4%) had poorly/undifferentiated carcinoma. Of the 68 patients, 32 (47%) had received definitive RT. Of these, 23 had received external beam RT and 9 brachytherapy. Of the remaining 36 patients, 3 (4%) underwent preoperative external beam RT and 33 (49%) postoperative external beam RT. Of the 68 patients, 13 (19%) received neck RT. The median dose for patients receiving definitive and postoperative RT was 65 and 58.2 Gy, respectively. The median follow-up for the entire cohort was 11 years (range, 2.4-30.1 years). Results: Of the 68 patients, 19 (28%) developed a locoregional relapse, 14 (21%) locally and 5 (7%) regionally. The local control rate at 5 and 10 years was 86% and 76%, respectively. The disease-specific survival rate was 86% and 78%, and the overall survival rate was 82% and 62% at 5 and 10 years, respectively. Conclusion: This extended follow-up of our institutional experience has demonstrated that RT can provide durable long-term locoregional control and survival outcomes for patients with carcinoma of the nasal cavity and septum.

Original languageEnglish (US)
Pages (from-to)401-406
Number of pages6
JournalInternational Journal of Radiation Oncology Biology Physics
Volume71
Issue number2
DOIs
StatePublished - Jun 1 2008

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Nasal Cavity
radiation therapy
Radiotherapy
cancer
cavities
Nasal Septum
septum
Neoplasms
Carcinoma
Survival Rate
Adenoid Cystic Carcinoma
prognosis
Brachytherapy
Squamous Cell Carcinoma
Adenocarcinoma
Neck
Recurrence
dosage
Survival

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

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Long-Term Radiotherapy Outcomes for Nasal Cavity and Septal Cancers. / Allen, Matthew W.; Schwartz, David; Rana, Vishal; Adapala, Pranshanth; Morrison, William H.; Hanna, Ehab Y.; Weber, Randal S.; Garden, Adam S.; Ang, K. Kian.

In: International Journal of Radiation Oncology Biology Physics, Vol. 71, No. 2, 01.06.2008, p. 401-406.

Research output: Contribution to journalArticle

Allen, MW, Schwartz, D, Rana, V, Adapala, P, Morrison, WH, Hanna, EY, Weber, RS, Garden, AS & Ang, KK 2008, 'Long-Term Radiotherapy Outcomes for Nasal Cavity and Septal Cancers', International Journal of Radiation Oncology Biology Physics, vol. 71, no. 2, pp. 401-406. https://doi.org/10.1016/j.ijrobp.2007.10.031
Allen, Matthew W. ; Schwartz, David ; Rana, Vishal ; Adapala, Pranshanth ; Morrison, William H. ; Hanna, Ehab Y. ; Weber, Randal S. ; Garden, Adam S. ; Ang, K. Kian. / Long-Term Radiotherapy Outcomes for Nasal Cavity and Septal Cancers. In: International Journal of Radiation Oncology Biology Physics. 2008 ; Vol. 71, No. 2. pp. 401-406.
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AU - Morrison, William H.

AU - Hanna, Ehab Y.

AU - Weber, Randal S.

AU - Garden, Adam S.

AU - Ang, K. Kian

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AB - Purpose: Carcinoma of the nasal cavity and septum has historically been associated with a poor prognosis. This report updates the long-term outcomes for radiotherapy (RT) of this disease site at the University of Texas M.D. Anderson Cancer Center. Methods and Materials: A retrospective analysis was performed on the data from 68 patients diagnosed with histologically proven carcinoma of the nasal cavity or septum treated with RT for curative intent between 1969 and 2000. The disease histologic type was as follows: 45 (66%) had squamous cell carcinoma, 12 (18%) had adenoid cystic carcinoma, 8 (12%) had adenocarcinoma, and 3 (4%) had poorly/undifferentiated carcinoma. Of the 68 patients, 32 (47%) had received definitive RT. Of these, 23 had received external beam RT and 9 brachytherapy. Of the remaining 36 patients, 3 (4%) underwent preoperative external beam RT and 33 (49%) postoperative external beam RT. Of the 68 patients, 13 (19%) received neck RT. The median dose for patients receiving definitive and postoperative RT was 65 and 58.2 Gy, respectively. The median follow-up for the entire cohort was 11 years (range, 2.4-30.1 years). Results: Of the 68 patients, 19 (28%) developed a locoregional relapse, 14 (21%) locally and 5 (7%) regionally. The local control rate at 5 and 10 years was 86% and 76%, respectively. The disease-specific survival rate was 86% and 78%, and the overall survival rate was 82% and 62% at 5 and 10 years, respectively. Conclusion: This extended follow-up of our institutional experience has demonstrated that RT can provide durable long-term locoregional control and survival outcomes for patients with carcinoma of the nasal cavity and septum.

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