Long-term results of two prospective trials of preoperative external beam radiotherapy for localized intermediate- or high-grade retroperitoneal soft tissue sarcoma

Timothy M. Pawlik, Peter W.T. Pisters, Lynn Mikula, Barry W. Feig, Kelly K. Hunt, Janice N. Cormier, Matthew Ballo, Charles N. Catton, Julia J. Jones, Brian O'Sullivan, Raphael E. Pollock, Carol J. Swallow

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Abstract

Background: The reported data on surgery plus radiotherapy for retroperitoneal soft tissue sarcomas (RPS) have been mostly from retrospective studies. We evaluated the long-term outcome of patients with operable RPS who were treated with protocol-based preoperative radiotherapy followed by complete surgical resection. Methods: Data from two prospective trials that included preoperative radiotherapy and surgery for patients with radiographically resectable RPS were combined to define long-term relapse rates and survival. Results: Seventy-two patients with intermediate- or high-grade RPS were treated with preoperative radiotherapy (median dose, 45 Gy; range, 18.0-50.4 Gy). Fifty-four patients (75%) had primary RPS, whereas 18 (25%) had recurrent disease. The median tumor size was 15.5 cm. Sixty-four patients completed the planned preoperative radiotherapy; 57 (89%) underwent laparotomy with curative intent, and 54 (95%) had a macroscopically complete (R0 or R1) resection. With a median follow-up of 40.3 months, 28 patients (52%) who received preoperative radiotherapy and underwent a macroscopically complete resection had recurrences. For the 54 patients who underwent R0 or R1 resection after preoperative radiotherapy, the 5-year local recurrence-free, disease-free, and overall survival rates were 60%, 46%, and 61%, respectively. The median overall survival has not been reached (>60 months). Conclusions: Patients with intermediate- or high-grade RPS treated with preoperative radiotherapy plus complete resection had a median survival >60 months. This compares favorably to historical data for similar patients treated with surgery alone.

Original languageEnglish (US)
Pages (from-to)508-517
Number of pages10
JournalAnnals of Surgical Oncology
Volume13
Issue number4
DOIs
StatePublished - Apr 1 2006
Externally publishedYes

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Sarcoma
Radiotherapy
Recurrence
Survival Rate
Survival
Laparotomy
Disease-Free Survival
Retrospective Studies

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

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Long-term results of two prospective trials of preoperative external beam radiotherapy for localized intermediate- or high-grade retroperitoneal soft tissue sarcoma. / Pawlik, Timothy M.; Pisters, Peter W.T.; Mikula, Lynn; Feig, Barry W.; Hunt, Kelly K.; Cormier, Janice N.; Ballo, Matthew; Catton, Charles N.; Jones, Julia J.; O'Sullivan, Brian; Pollock, Raphael E.; Swallow, Carol J.

In: Annals of Surgical Oncology, Vol. 13, No. 4, 01.04.2006, p. 508-517.

Research output: Contribution to journalArticle

Pawlik, TM, Pisters, PWT, Mikula, L, Feig, BW, Hunt, KK, Cormier, JN, Ballo, M, Catton, CN, Jones, JJ, O'Sullivan, B, Pollock, RE & Swallow, CJ 2006, 'Long-term results of two prospective trials of preoperative external beam radiotherapy for localized intermediate- or high-grade retroperitoneal soft tissue sarcoma', Annals of Surgical Oncology, vol. 13, no. 4, pp. 508-517. https://doi.org/10.1245/ASO.2006.05.035
Pawlik, Timothy M. ; Pisters, Peter W.T. ; Mikula, Lynn ; Feig, Barry W. ; Hunt, Kelly K. ; Cormier, Janice N. ; Ballo, Matthew ; Catton, Charles N. ; Jones, Julia J. ; O'Sullivan, Brian ; Pollock, Raphael E. ; Swallow, Carol J. / Long-term results of two prospective trials of preoperative external beam radiotherapy for localized intermediate- or high-grade retroperitoneal soft tissue sarcoma. In: Annals of Surgical Oncology. 2006 ; Vol. 13, No. 4. pp. 508-517.
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abstract = "Background: The reported data on surgery plus radiotherapy for retroperitoneal soft tissue sarcomas (RPS) have been mostly from retrospective studies. We evaluated the long-term outcome of patients with operable RPS who were treated with protocol-based preoperative radiotherapy followed by complete surgical resection. Methods: Data from two prospective trials that included preoperative radiotherapy and surgery for patients with radiographically resectable RPS were combined to define long-term relapse rates and survival. Results: Seventy-two patients with intermediate- or high-grade RPS were treated with preoperative radiotherapy (median dose, 45 Gy; range, 18.0-50.4 Gy). Fifty-four patients (75{\%}) had primary RPS, whereas 18 (25{\%}) had recurrent disease. The median tumor size was 15.5 cm. Sixty-four patients completed the planned preoperative radiotherapy; 57 (89{\%}) underwent laparotomy with curative intent, and 54 (95{\%}) had a macroscopically complete (R0 or R1) resection. With a median follow-up of 40.3 months, 28 patients (52{\%}) who received preoperative radiotherapy and underwent a macroscopically complete resection had recurrences. For the 54 patients who underwent R0 or R1 resection after preoperative radiotherapy, the 5-year local recurrence-free, disease-free, and overall survival rates were 60{\%}, 46{\%}, and 61{\%}, respectively. The median overall survival has not been reached (>60 months). Conclusions: Patients with intermediate- or high-grade RPS treated with preoperative radiotherapy plus complete resection had a median survival >60 months. This compares favorably to historical data for similar patients treated with surgery alone.",
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T1 - Long-term results of two prospective trials of preoperative external beam radiotherapy for localized intermediate- or high-grade retroperitoneal soft tissue sarcoma

AU - Pawlik, Timothy M.

AU - Pisters, Peter W.T.

AU - Mikula, Lynn

AU - Feig, Barry W.

AU - Hunt, Kelly K.

AU - Cormier, Janice N.

AU - Ballo, Matthew

AU - Catton, Charles N.

AU - Jones, Julia J.

AU - O'Sullivan, Brian

AU - Pollock, Raphael E.

AU - Swallow, Carol J.

PY - 2006/4/1

Y1 - 2006/4/1

N2 - Background: The reported data on surgery plus radiotherapy for retroperitoneal soft tissue sarcomas (RPS) have been mostly from retrospective studies. We evaluated the long-term outcome of patients with operable RPS who were treated with protocol-based preoperative radiotherapy followed by complete surgical resection. Methods: Data from two prospective trials that included preoperative radiotherapy and surgery for patients with radiographically resectable RPS were combined to define long-term relapse rates and survival. Results: Seventy-two patients with intermediate- or high-grade RPS were treated with preoperative radiotherapy (median dose, 45 Gy; range, 18.0-50.4 Gy). Fifty-four patients (75%) had primary RPS, whereas 18 (25%) had recurrent disease. The median tumor size was 15.5 cm. Sixty-four patients completed the planned preoperative radiotherapy; 57 (89%) underwent laparotomy with curative intent, and 54 (95%) had a macroscopically complete (R0 or R1) resection. With a median follow-up of 40.3 months, 28 patients (52%) who received preoperative radiotherapy and underwent a macroscopically complete resection had recurrences. For the 54 patients who underwent R0 or R1 resection after preoperative radiotherapy, the 5-year local recurrence-free, disease-free, and overall survival rates were 60%, 46%, and 61%, respectively. The median overall survival has not been reached (>60 months). Conclusions: Patients with intermediate- or high-grade RPS treated with preoperative radiotherapy plus complete resection had a median survival >60 months. This compares favorably to historical data for similar patients treated with surgery alone.

AB - Background: The reported data on surgery plus radiotherapy for retroperitoneal soft tissue sarcomas (RPS) have been mostly from retrospective studies. We evaluated the long-term outcome of patients with operable RPS who were treated with protocol-based preoperative radiotherapy followed by complete surgical resection. Methods: Data from two prospective trials that included preoperative radiotherapy and surgery for patients with radiographically resectable RPS were combined to define long-term relapse rates and survival. Results: Seventy-two patients with intermediate- or high-grade RPS were treated with preoperative radiotherapy (median dose, 45 Gy; range, 18.0-50.4 Gy). Fifty-four patients (75%) had primary RPS, whereas 18 (25%) had recurrent disease. The median tumor size was 15.5 cm. Sixty-four patients completed the planned preoperative radiotherapy; 57 (89%) underwent laparotomy with curative intent, and 54 (95%) had a macroscopically complete (R0 or R1) resection. With a median follow-up of 40.3 months, 28 patients (52%) who received preoperative radiotherapy and underwent a macroscopically complete resection had recurrences. For the 54 patients who underwent R0 or R1 resection after preoperative radiotherapy, the 5-year local recurrence-free, disease-free, and overall survival rates were 60%, 46%, and 61%, respectively. The median overall survival has not been reached (>60 months). Conclusions: Patients with intermediate- or high-grade RPS treated with preoperative radiotherapy plus complete resection had a median survival >60 months. This compares favorably to historical data for similar patients treated with surgery alone.

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U2 - 10.1245/ASO.2006.05.035

DO - 10.1245/ASO.2006.05.035

M3 - Article

VL - 13

SP - 508

EP - 517

JO - Annals of Surgical Oncology

JF - Annals of Surgical Oncology

SN - 1068-9265

IS - 4

ER -