Long-term survival after surgical management of neuroendocrine hepatic metastases

Evan Glazer, Jennifer F. Tseng, Waddah Al-Refaie, Carmen C. Solorzano, Ping Liu, Katherine A. Willborn, Eddie K. Abdalla, Jean Nicolas Vauthey, Steven A. Curley

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

Background: Surgical cytoreduction and endocrine blockade are important options for care for neuroendocrine liver metastases. We investigated the long-term survival of patients surgically treated for hepatic neuroendocrine metastases. Methods: Patients (n = 172) undergoing operations for neuroendocrine liver metastases from any primary were identified from a prospective liver database. Recorded data and medical record review were used to analyse the type of procedure, length of hospital stay, peri-operative morbidity, tumour recurrence, progression,and survival. Results: The median age was 56.8 years (range 11.5-80.7 years). 48.3% of patients were female. Median overall survival was 9.6 years (range 89 days to 22 years). On multivariate analysis, lung/thymic primaries were associated with worse survival [hazard ratio (HR): 15.6, confidence interval (CI): 4.3-56.8, P = 0.002]. Severe post-operative complications were also associated with worse long-term survival (P < 0.001). A positive resection margin status (R1) was not associated with a worse overall survival probability (P ̃ 0.8). Discussion: Early and aggressive surgical management of hepatic metastases from neuroendocrine tumours is associated with significant long-term survival rates. Radiofrequency ablation is a reasonable option if a lesion is unresectable. R1 resections, unlike many other cancers, are not associated with a worse overall survival.

Original languageEnglish (US)
Pages (from-to)427-433
Number of pages7
JournalHPB
Volume12
Issue number6
DOIs
StatePublished - Jan 1 2010

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Neoplasm Metastasis
Survival
Liver
Length of Stay
Neuroendocrine Tumors
Medical Records
Neoplasms
Multivariate Analysis
Survival Rate
Databases
Confidence Intervals
Morbidity
Recurrence
Lung

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Glazer, E., Tseng, J. F., Al-Refaie, W., Solorzano, C. C., Liu, P., Willborn, K. A., ... Curley, S. A. (2010). Long-term survival after surgical management of neuroendocrine hepatic metastases. HPB, 12(6), 427-433. https://doi.org/10.1111/j.1477-2574.2010.00198.x

Long-term survival after surgical management of neuroendocrine hepatic metastases. / Glazer, Evan; Tseng, Jennifer F.; Al-Refaie, Waddah; Solorzano, Carmen C.; Liu, Ping; Willborn, Katherine A.; Abdalla, Eddie K.; Vauthey, Jean Nicolas; Curley, Steven A.

In: HPB, Vol. 12, No. 6, 01.01.2010, p. 427-433.

Research output: Contribution to journalArticle

Glazer, E, Tseng, JF, Al-Refaie, W, Solorzano, CC, Liu, P, Willborn, KA, Abdalla, EK, Vauthey, JN & Curley, SA 2010, 'Long-term survival after surgical management of neuroendocrine hepatic metastases', HPB, vol. 12, no. 6, pp. 427-433. https://doi.org/10.1111/j.1477-2574.2010.00198.x
Glazer E, Tseng JF, Al-Refaie W, Solorzano CC, Liu P, Willborn KA et al. Long-term survival after surgical management of neuroendocrine hepatic metastases. HPB. 2010 Jan 1;12(6):427-433. https://doi.org/10.1111/j.1477-2574.2010.00198.x
Glazer, Evan ; Tseng, Jennifer F. ; Al-Refaie, Waddah ; Solorzano, Carmen C. ; Liu, Ping ; Willborn, Katherine A. ; Abdalla, Eddie K. ; Vauthey, Jean Nicolas ; Curley, Steven A. / Long-term survival after surgical management of neuroendocrine hepatic metastases. In: HPB. 2010 ; Vol. 12, No. 6. pp. 427-433.
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