Longitudinal study of CD4+ cell counts in HIV-negative pregnant patients

Craig Towers, Pamela J. Rumney, Mark G. Ghamsary

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective.To evaluate the absolute CD4+, CD8+, and lymphocyte cell counts and percentages from the first trimester through 612 weeks post-delivery in normal human immunodeficiency virus (HIV)-negative pregnant patients. Methods.A longitudinal laboratory analysis was performed during pregnancy that involved 51 HIV-negative subjects with blood analysis obtained in all trimesters, at delivery, and 612 weeks post-delivery. Twenty-five HIV-negative non-pregnant controls were also evaluated. Blood was analysed for absolute CD4+, CD8+, and lymphocyte cell counts and percentages. Means, standard deviations, trends, and differences were examined. Results.The mean white blood cell (WBC) count is elevated above the non-pregnant state and this parameter increases through the pregnancy up to and including parturition. The mean absolute lymphocyte cell count, lymphocyte percentage, and absolute CD4+ cell count are significantly lower during pregnancy and the progression through pregnancy appears U-shaped. The mean absolute CD8+ cell count is not significantly different. The CD4+ and CD8+ percentages are higher during pregnancy and this elevation persists into the 612 week post-delivery time period. A 3-digit drop in CD4+ percentage is common during pregnancy between blood draws; whereas, a 30 decrease or more in absolute CD4+ cell count is rare. Conclusions.By longitudinal analysis, pregnancy appears to significantly elevate the mean values of the WBC count, CD4+ percentage, and CD8+ percentage, but significantly decreases the absolute lymphocyte count, lymphocyte percentage, and absolute CD4+ cell count when compared to non-pregnant controls. The mean absolute CD8+ cell count appears to be unaffected.

Original languageEnglish (US)
Pages (from-to)1091-1096
Number of pages6
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume23
Issue number10
DOIs
StatePublished - Oct 1 2010

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CD4 Lymphocyte Count
Longitudinal Studies
HIV
Pregnancy
Lymphocyte Count
Cell Count
Leukocyte Count
Lymphocytes
First Pregnancy Trimester
Parturition

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Longitudinal study of CD4+ cell counts in HIV-negative pregnant patients. / Towers, Craig; Rumney, Pamela J.; Ghamsary, Mark G.

In: Journal of Maternal-Fetal and Neonatal Medicine, Vol. 23, No. 10, 01.10.2010, p. 1091-1096.

Research output: Contribution to journalArticle

Towers, Craig ; Rumney, Pamela J. ; Ghamsary, Mark G. / Longitudinal study of CD4+ cell counts in HIV-negative pregnant patients. In: Journal of Maternal-Fetal and Neonatal Medicine. 2010 ; Vol. 23, No. 10. pp. 1091-1096.
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