Longitudinal surveillance on antibiogram of important Gram-positive pathogens in Southern China, 2001 to 2015

Zhenbo Xu, Jinhong Xie, Brian Peters, Bing Li, Lin Li, Guangchao Yu, Mark E. Shirtliff

Research output: Contribution to journalArticle

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Abstract

Objectives A longitudinal surveillance aimed to investigate the antibiogram of three genus of important Gram-positive pathogens in Southern China during 2001–2015. Methods A total of 3849 Staphylococcus, Enterococcus and Streptococcus strains were isolated from Southern China during 2001–2015. Bacteria identification was performed by colony morphology, Gram staining, the API commercial kit and the Vitek 2 automated system. Antimicrobial susceptibility testing was determined by disk diffusion method and MIC method. Results As sampling site was concerned, 51.4% of Staphylococcus strains were isolated from sputum, whereas urinary tract remained the dominant infection site among Enterococcus and Streptococcus. According to the antimicrobial susceptibility, three genus of important Gram-positive pathogens showed high resistance against erythromycin, tetracycline, ciprofloxacin and clindamycin. Resistance rates to penicillins (penicillin, oxacillin, ampicillin) were high as well, with the exception of E. faecalis and Streptococcus. Overall, resistance rates against methicillin (oxacillin) were 63.2% in S. aureus and 76.2% in coagulase-negative Staphylococcus (CNS), along with continuous increases during the study. VRSA and vancomycin-resistant coagulase-negative Staphylococcus only appeared in 2011–2015. Sight decline was obtained for the vancomycin resistance of E. faecalis, while vancomycin-resistant E. faecium only appeared in 2011–2015, with its intermediate rate decreasing. Significant decrease in penicillin-resistant Streptococcus pneumonia (PRSP) was observed during studied period. Glycopeptide antibiotic remained highly effective to Staphylococcus, Enterococcus and Streptococcus (resistance rates <5%). Conclusions Despite decline obtained for some antibiotic agents resistance during 2001–2015, antimicrobial resistance among Gram-positive pathogens still remained high in Southern China. This study may aid in the guidance for appropriate therapeutic strategy of infections caused by nosocomial pathogens.

Original languageEnglish (US)
Pages (from-to)80-86
Number of pages7
JournalMicrobial Pathogenesis
Volume103
DOIs
StatePublished - Feb 1 2017

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Microbial Sensitivity Tests
Staphylococcus
China
Enterococcus
Streptococcus
Penicillins
Oxacillin
Coagulase
Vancomycin
Vancomycin Resistance
Methicillin
Clindamycin
Glycopeptides
Enterococcus faecalis
Erythromycin
Ampicillin
Ciprofloxacin
Microbial Drug Resistance
Cross Infection
Streptococcus pneumoniae

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Infectious Diseases

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Longitudinal surveillance on antibiogram of important Gram-positive pathogens in Southern China, 2001 to 2015. / Xu, Zhenbo; Xie, Jinhong; Peters, Brian; Li, Bing; Li, Lin; Yu, Guangchao; Shirtliff, Mark E.

In: Microbial Pathogenesis, Vol. 103, 01.02.2017, p. 80-86.

Research output: Contribution to journalArticle

Xu, Zhenbo ; Xie, Jinhong ; Peters, Brian ; Li, Bing ; Li, Lin ; Yu, Guangchao ; Shirtliff, Mark E. / Longitudinal surveillance on antibiogram of important Gram-positive pathogens in Southern China, 2001 to 2015. In: Microbial Pathogenesis. 2017 ; Vol. 103. pp. 80-86.
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abstract = "Objectives A longitudinal surveillance aimed to investigate the antibiogram of three genus of important Gram-positive pathogens in Southern China during 2001–2015. Methods A total of 3849 Staphylococcus, Enterococcus and Streptococcus strains were isolated from Southern China during 2001–2015. Bacteria identification was performed by colony morphology, Gram staining, the API commercial kit and the Vitek 2 automated system. Antimicrobial susceptibility testing was determined by disk diffusion method and MIC method. Results As sampling site was concerned, 51.4{\%} of Staphylococcus strains were isolated from sputum, whereas urinary tract remained the dominant infection site among Enterococcus and Streptococcus. According to the antimicrobial susceptibility, three genus of important Gram-positive pathogens showed high resistance against erythromycin, tetracycline, ciprofloxacin and clindamycin. Resistance rates to penicillins (penicillin, oxacillin, ampicillin) were high as well, with the exception of E. faecalis and Streptococcus. Overall, resistance rates against methicillin (oxacillin) were 63.2{\%} in S. aureus and 76.2{\%} in coagulase-negative Staphylococcus (CNS), along with continuous increases during the study. VRSA and vancomycin-resistant coagulase-negative Staphylococcus only appeared in 2011–2015. Sight decline was obtained for the vancomycin resistance of E. faecalis, while vancomycin-resistant E. faecium only appeared in 2011–2015, with its intermediate rate decreasing. Significant decrease in penicillin-resistant Streptococcus pneumonia (PRSP) was observed during studied period. Glycopeptide antibiotic remained highly effective to Staphylococcus, Enterococcus and Streptococcus (resistance rates <5{\%}). Conclusions Despite decline obtained for some antibiotic agents resistance during 2001–2015, antimicrobial resistance among Gram-positive pathogens still remained high in Southern China. This study may aid in the guidance for appropriate therapeutic strategy of infections caused by nosocomial pathogens.",
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