Low-fat dietary pattern and breast cancer mortality in the Women's Health Initiative randomized controlled trial

Rowan T. Chlebowski, Aaron K. Aragaki, Garnet L. Anderson, Cynthia A. Thomson, Jo Ann E. Manson, Michael S. Simon, Barbara V. Howard, Thomas E. Rohan, Linda Snetselar, Dorothy Lane, Wendy Barrington, Mara Z. Vitolins, Catherine Womack, Lihong Qi, Lifang Hou, Fridtjof Thomas, Ross L. Prentice

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Abstract

Purpose: Earlier Women's Health Initiative Dietary Modification trial findings suggested that a low-fat eating pattern may reduce breast cancers with greater mortality. Therefore, as a primary outcome-related analysis from a randomized prevention trial, we examined the long-term influence of this intervention on deaths as a result of and after breast cancer during 8.5 years (median) of dietary intervention and cumulatively for all breast cancers diagnosed during 16.1 years (median) of follow-up. Patients and Methods: The trial randomly assigned 48,835 postmenopausal women with normal mammograms and without prior breast cancer from 1993 to 1998 at 40 US clinical centers to a dietary intervention with goals of a reduction of fat intake to 20 % of energy and an increased intake of fruits, vegetables, and grains (40 % ; n = 19,541) or to a usual diet comparison (60 % ; n = 29,294). Results: In the dietary group, fat intake and body weight decreased (all P > .001). During the 8.5-year dietary intervention, with 1,764 incident breast cancers, fewer deaths occurred as a result of breast cancer in the dietary group, which was not statistically significant (27 deaths [0.016 % per year] v 61 deaths [0.024 % per year]; hazard ratio [HR], 0.67; 95 % CI, 0.43 to 1.06; P = .08). During the same period, deaths after breast cancer (n = 134) were significantly reduced (40 deaths [0.025 % per year] v 94 deaths [0.038 % per year]; HR, 0.65; 95 % CI, 0.45 to 0.94; P = .02) by the dietary intervention. During the 16.1-year follow-up, with 3,030 incident breast cancers, deaths after breast cancer also were significantly reduced (234 deaths [0.085 % per year] v 443 deaths [0.11 % per year]; HR, 0.82; 95 % CI, 0.70 to 0.96; P = .01) in the dietary group. Conclusion: Compared with a usual diet comparison group, a low-fat dietary pattern led to a lower incidence of deaths after breast cancer.

Original languageEnglish (US)
Pages (from-to)2919-2926
Number of pages8
JournalJournal of Clinical Oncology
Volume35
Issue number25
DOIs
StatePublished - Sep 1 2017

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Dietary Fats
Women's Health
Randomized Controlled Trials
Breast Neoplasms
Mortality
Fats
Diet
Diet Therapy
Energy Intake
Vegetables
Fruit
Eating
Body Weight

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Chlebowski, R. T., Aragaki, A. K., Anderson, G. L., Thomson, C. A., Manson, J. A. E., Simon, M. S., ... Prentice, R. L. (2017). Low-fat dietary pattern and breast cancer mortality in the Women's Health Initiative randomized controlled trial. Journal of Clinical Oncology, 35(25), 2919-2926. https://doi.org/10.1200/JCO.2016.72.0326

Low-fat dietary pattern and breast cancer mortality in the Women's Health Initiative randomized controlled trial. / Chlebowski, Rowan T.; Aragaki, Aaron K.; Anderson, Garnet L.; Thomson, Cynthia A.; Manson, Jo Ann E.; Simon, Michael S.; Howard, Barbara V.; Rohan, Thomas E.; Snetselar, Linda; Lane, Dorothy; Barrington, Wendy; Vitolins, Mara Z.; Womack, Catherine; Qi, Lihong; Hou, Lifang; Thomas, Fridtjof; Prentice, Ross L.

In: Journal of Clinical Oncology, Vol. 35, No. 25, 01.09.2017, p. 2919-2926.

Research output: Contribution to journalArticle

Chlebowski, RT, Aragaki, AK, Anderson, GL, Thomson, CA, Manson, JAE, Simon, MS, Howard, BV, Rohan, TE, Snetselar, L, Lane, D, Barrington, W, Vitolins, MZ, Womack, C, Qi, L, Hou, L, Thomas, F & Prentice, RL 2017, 'Low-fat dietary pattern and breast cancer mortality in the Women's Health Initiative randomized controlled trial', Journal of Clinical Oncology, vol. 35, no. 25, pp. 2919-2926. https://doi.org/10.1200/JCO.2016.72.0326
Chlebowski, Rowan T. ; Aragaki, Aaron K. ; Anderson, Garnet L. ; Thomson, Cynthia A. ; Manson, Jo Ann E. ; Simon, Michael S. ; Howard, Barbara V. ; Rohan, Thomas E. ; Snetselar, Linda ; Lane, Dorothy ; Barrington, Wendy ; Vitolins, Mara Z. ; Womack, Catherine ; Qi, Lihong ; Hou, Lifang ; Thomas, Fridtjof ; Prentice, Ross L. / Low-fat dietary pattern and breast cancer mortality in the Women's Health Initiative randomized controlled trial. In: Journal of Clinical Oncology. 2017 ; Vol. 35, No. 25. pp. 2919-2926.
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T1 - Low-fat dietary pattern and breast cancer mortality in the Women's Health Initiative randomized controlled trial

AU - Chlebowski, Rowan T.

AU - Aragaki, Aaron K.

AU - Anderson, Garnet L.

AU - Thomson, Cynthia A.

AU - Manson, Jo Ann E.

AU - Simon, Michael S.

AU - Howard, Barbara V.

AU - Rohan, Thomas E.

AU - Snetselar, Linda

AU - Lane, Dorothy

AU - Barrington, Wendy

AU - Vitolins, Mara Z.

AU - Womack, Catherine

AU - Qi, Lihong

AU - Hou, Lifang

AU - Thomas, Fridtjof

AU - Prentice, Ross L.

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Purpose: Earlier Women's Health Initiative Dietary Modification trial findings suggested that a low-fat eating pattern may reduce breast cancers with greater mortality. Therefore, as a primary outcome-related analysis from a randomized prevention trial, we examined the long-term influence of this intervention on deaths as a result of and after breast cancer during 8.5 years (median) of dietary intervention and cumulatively for all breast cancers diagnosed during 16.1 years (median) of follow-up. Patients and Methods: The trial randomly assigned 48,835 postmenopausal women with normal mammograms and without prior breast cancer from 1993 to 1998 at 40 US clinical centers to a dietary intervention with goals of a reduction of fat intake to 20 % of energy and an increased intake of fruits, vegetables, and grains (40 % ; n = 19,541) or to a usual diet comparison (60 % ; n = 29,294). Results: In the dietary group, fat intake and body weight decreased (all P > .001). During the 8.5-year dietary intervention, with 1,764 incident breast cancers, fewer deaths occurred as a result of breast cancer in the dietary group, which was not statistically significant (27 deaths [0.016 % per year] v 61 deaths [0.024 % per year]; hazard ratio [HR], 0.67; 95 % CI, 0.43 to 1.06; P = .08). During the same period, deaths after breast cancer (n = 134) were significantly reduced (40 deaths [0.025 % per year] v 94 deaths [0.038 % per year]; HR, 0.65; 95 % CI, 0.45 to 0.94; P = .02) by the dietary intervention. During the 16.1-year follow-up, with 3,030 incident breast cancers, deaths after breast cancer also were significantly reduced (234 deaths [0.085 % per year] v 443 deaths [0.11 % per year]; HR, 0.82; 95 % CI, 0.70 to 0.96; P = .01) in the dietary group. Conclusion: Compared with a usual diet comparison group, a low-fat dietary pattern led to a lower incidence of deaths after breast cancer.

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