Low-Power 2-MHz Pulsed-Wave Transcranial Ultrasound Reduces Ischemic Brain Damage in Rats

Andrei Alexandrov, Kristian Barlinn, Roger Strong, Anne Alexandrov, Jaroslaw Aronowski

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

It is largely unknown whether prolonged insonation with ultrasound impacts the ischemic brain tissue by itself. Our goal was to evaluate safety and the effect of high-frequency ultrasound on infarct volume in rats. Thirty-two Long-Evans rats with permanent middle cerebral and carotid artery occlusions received either 2-MHz ultrasound at two levels of insonation power (128 or 10 mW) or no ultrasound (controls). We measured cerebral hemorrhage, indirect and direct infarct volume as well as edema volume at 24 h. No cerebral hemorrhages were detected in all animals. Exposure to low-power (10 mW) ultrasound resulted in a significantly decreased indirect infarct volume (p = 0. 0039), direct infarct volume (p = 0. 0031), and brain edema volume (p = 0. 01) compared with controls. High-power (128 mW) ultrasound had no significant effects. An additional experiment with India ink showed a greater intravascular penetration of dye into ischemic tissues exposed to low-power ultrasound. Insonation with high-frequency, low-power ultrasound reduces ischemic brain damage in rat. Its effect on edema reduction and possible promotion of microcirculation could be used to facilitate drug and nutrient delivery to ischemic areas.

Original languageEnglish (US)
Pages (from-to)376-381
Number of pages6
JournalTranslational Stroke Research
Volume2
Issue number3
DOIs
StatePublished - Jan 1 2011

Fingerprint

Cerebral Hemorrhage
Edema
Long Evans Rats
Middle Cerebral Artery Infarction
Brain Edema
Brain
Microcirculation
Carotid Arteries
Coloring Agents
Safety
Food
Pharmaceutical Preparations
Ultrasonic Waves
chinese ink

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Low-Power 2-MHz Pulsed-Wave Transcranial Ultrasound Reduces Ischemic Brain Damage in Rats. / Alexandrov, Andrei; Barlinn, Kristian; Strong, Roger; Alexandrov, Anne; Aronowski, Jaroslaw.

In: Translational Stroke Research, Vol. 2, No. 3, 01.01.2011, p. 376-381.

Research output: Contribution to journalArticle

Alexandrov, Andrei ; Barlinn, Kristian ; Strong, Roger ; Alexandrov, Anne ; Aronowski, Jaroslaw. / Low-Power 2-MHz Pulsed-Wave Transcranial Ultrasound Reduces Ischemic Brain Damage in Rats. In: Translational Stroke Research. 2011 ; Vol. 2, No. 3. pp. 376-381.
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