Low testosterone levels and decline in physical performance and muscle strength in older men

Findings from two prospective cohort studies

Laura A. Schaap, Saskia M.F. Pluijm, Dorly J.H. Deeg, Brenda W. Penninx, Barbara J. Nicklas, Paul Lips, Tamara B. Harris, Anne B. Newman, Steve B. Kritchevsky, Jane A. Cauley, Bret H. Goodpaster, Frances Tylavsky, Kristine Yaffe, Marjolein Visser

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Objective: Progressive declines in serum levels of testosterone parallel the decline in physical performance and muscle strength in ageing men, although findings are not conclusive. We examined whether levels of testosterone were associated with 3-year decline in physical performance and muscle strength in older men. Design: Longitudinal data were available for 486 men (mean age 74.9 years, SD 6.4) from the Longitudinal Ageing Study Amsterdam (LASA) and 1071 well-functioning men (mean age 73.7 years, SD 2.8) from the Health, Ageing and Body Composition (Health ABC) study. Measurements: Three-year change in physical performance score and grip strength according to categories of total testosterone (TT) and free testosterone (FT) levels. Results: The mean 3-year change in physical performance was -1.1 (SD 2.7, -13.6%) in LASA and -0.3 (SD 1.5, -2.9%) in Health ABC. The mean 3-year change in grip strength was -9.7 kg (SD 12.2, -13.2%) in LASA and -4.4 kg (SD 11.4, -5.8%) in Health ABC. Low levels of TT were not associated with decline in physical performance or with decline in muscle strength [e.g. mean change in physical performance -1.09 (SD 0.26) in the lowest quartile (Q1) and -0.88 (0.24) in the highest quartile (Q4) of total testosterone in LASA, and -0.26 (0.07) vs. -0.36 (0.11) in Health ABC]. Similar results were found for FT. Conclusions: Low levels of TT and FT were neither associated with 3-year decline in physical performance nor with 3-year decline in muscle strength in two independent samples of older men.

Original languageEnglish (US)
Pages (from-to)42-50
Number of pages9
JournalClinical Endocrinology
Volume68
Issue number1
DOIs
StatePublished - Jan 1 2008

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Muscle Strength
Testosterone
Cohort Studies
Prospective Studies
Body Composition
Longitudinal Studies
Health
Hand Strength
Serum

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Low testosterone levels and decline in physical performance and muscle strength in older men : Findings from two prospective cohort studies. / Schaap, Laura A.; Pluijm, Saskia M.F.; Deeg, Dorly J.H.; Penninx, Brenda W.; Nicklas, Barbara J.; Lips, Paul; Harris, Tamara B.; Newman, Anne B.; Kritchevsky, Steve B.; Cauley, Jane A.; Goodpaster, Bret H.; Tylavsky, Frances; Yaffe, Kristine; Visser, Marjolein.

In: Clinical Endocrinology, Vol. 68, No. 1, 01.01.2008, p. 42-50.

Research output: Contribution to journalArticle

Schaap, LA, Pluijm, SMF, Deeg, DJH, Penninx, BW, Nicklas, BJ, Lips, P, Harris, TB, Newman, AB, Kritchevsky, SB, Cauley, JA, Goodpaster, BH, Tylavsky, F, Yaffe, K & Visser, M 2008, 'Low testosterone levels and decline in physical performance and muscle strength in older men: Findings from two prospective cohort studies', Clinical Endocrinology, vol. 68, no. 1, pp. 42-50. https://doi.org/10.1111/j.1365-2265.2007.02997.x
Schaap, Laura A. ; Pluijm, Saskia M.F. ; Deeg, Dorly J.H. ; Penninx, Brenda W. ; Nicklas, Barbara J. ; Lips, Paul ; Harris, Tamara B. ; Newman, Anne B. ; Kritchevsky, Steve B. ; Cauley, Jane A. ; Goodpaster, Bret H. ; Tylavsky, Frances ; Yaffe, Kristine ; Visser, Marjolein. / Low testosterone levels and decline in physical performance and muscle strength in older men : Findings from two prospective cohort studies. In: Clinical Endocrinology. 2008 ; Vol. 68, No. 1. pp. 42-50.
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abstract = "Objective: Progressive declines in serum levels of testosterone parallel the decline in physical performance and muscle strength in ageing men, although findings are not conclusive. We examined whether levels of testosterone were associated with 3-year decline in physical performance and muscle strength in older men. Design: Longitudinal data were available for 486 men (mean age 74.9 years, SD 6.4) from the Longitudinal Ageing Study Amsterdam (LASA) and 1071 well-functioning men (mean age 73.7 years, SD 2.8) from the Health, Ageing and Body Composition (Health ABC) study. Measurements: Three-year change in physical performance score and grip strength according to categories of total testosterone (TT) and free testosterone (FT) levels. Results: The mean 3-year change in physical performance was -1.1 (SD 2.7, -13.6{\%}) in LASA and -0.3 (SD 1.5, -2.9{\%}) in Health ABC. The mean 3-year change in grip strength was -9.7 kg (SD 12.2, -13.2{\%}) in LASA and -4.4 kg (SD 11.4, -5.8{\%}) in Health ABC. Low levels of TT were not associated with decline in physical performance or with decline in muscle strength [e.g. mean change in physical performance -1.09 (SD 0.26) in the lowest quartile (Q1) and -0.88 (0.24) in the highest quartile (Q4) of total testosterone in LASA, and -0.26 (0.07) vs. -0.36 (0.11) in Health ABC]. Similar results were found for FT. Conclusions: Low levels of TT and FT were neither associated with 3-year decline in physical performance nor with 3-year decline in muscle strength in two independent samples of older men.",
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T1 - Low testosterone levels and decline in physical performance and muscle strength in older men

T2 - Findings from two prospective cohort studies

AU - Schaap, Laura A.

AU - Pluijm, Saskia M.F.

AU - Deeg, Dorly J.H.

AU - Penninx, Brenda W.

AU - Nicklas, Barbara J.

AU - Lips, Paul

AU - Harris, Tamara B.

AU - Newman, Anne B.

AU - Kritchevsky, Steve B.

AU - Cauley, Jane A.

AU - Goodpaster, Bret H.

AU - Tylavsky, Frances

AU - Yaffe, Kristine

AU - Visser, Marjolein

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N2 - Objective: Progressive declines in serum levels of testosterone parallel the decline in physical performance and muscle strength in ageing men, although findings are not conclusive. We examined whether levels of testosterone were associated with 3-year decline in physical performance and muscle strength in older men. Design: Longitudinal data were available for 486 men (mean age 74.9 years, SD 6.4) from the Longitudinal Ageing Study Amsterdam (LASA) and 1071 well-functioning men (mean age 73.7 years, SD 2.8) from the Health, Ageing and Body Composition (Health ABC) study. Measurements: Three-year change in physical performance score and grip strength according to categories of total testosterone (TT) and free testosterone (FT) levels. Results: The mean 3-year change in physical performance was -1.1 (SD 2.7, -13.6%) in LASA and -0.3 (SD 1.5, -2.9%) in Health ABC. The mean 3-year change in grip strength was -9.7 kg (SD 12.2, -13.2%) in LASA and -4.4 kg (SD 11.4, -5.8%) in Health ABC. Low levels of TT were not associated with decline in physical performance or with decline in muscle strength [e.g. mean change in physical performance -1.09 (SD 0.26) in the lowest quartile (Q1) and -0.88 (0.24) in the highest quartile (Q4) of total testosterone in LASA, and -0.26 (0.07) vs. -0.36 (0.11) in Health ABC]. Similar results were found for FT. Conclusions: Low levels of TT and FT were neither associated with 3-year decline in physical performance nor with 3-year decline in muscle strength in two independent samples of older men.

AB - Objective: Progressive declines in serum levels of testosterone parallel the decline in physical performance and muscle strength in ageing men, although findings are not conclusive. We examined whether levels of testosterone were associated with 3-year decline in physical performance and muscle strength in older men. Design: Longitudinal data were available for 486 men (mean age 74.9 years, SD 6.4) from the Longitudinal Ageing Study Amsterdam (LASA) and 1071 well-functioning men (mean age 73.7 years, SD 2.8) from the Health, Ageing and Body Composition (Health ABC) study. Measurements: Three-year change in physical performance score and grip strength according to categories of total testosterone (TT) and free testosterone (FT) levels. Results: The mean 3-year change in physical performance was -1.1 (SD 2.7, -13.6%) in LASA and -0.3 (SD 1.5, -2.9%) in Health ABC. The mean 3-year change in grip strength was -9.7 kg (SD 12.2, -13.2%) in LASA and -4.4 kg (SD 11.4, -5.8%) in Health ABC. Low levels of TT were not associated with decline in physical performance or with decline in muscle strength [e.g. mean change in physical performance -1.09 (SD 0.26) in the lowest quartile (Q1) and -0.88 (0.24) in the highest quartile (Q4) of total testosterone in LASA, and -0.26 (0.07) vs. -0.36 (0.11) in Health ABC]. Similar results were found for FT. Conclusions: Low levels of TT and FT were neither associated with 3-year decline in physical performance nor with 3-year decline in muscle strength in two independent samples of older men.

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