Lower serum albumin concentration and change in muscle mass

The Health, Aging and Body Composition Study

Marjolein Visser, Stephen B. Kritchevsky, Anne B. Newman, Bret H. Goodpaster, Frances Tylavsky, Michael C. Nevitt, Tamara B. Harris

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

Background: Low albumin concentrations in older persons increase the risk of poor health outcomes, including functional decline. Objective: The aim of the study was to investigate the association between serum albumin concentration and skeletal muscle loss (sarcopenia) in old age. Design: Serum albumin concentration was measured in 1882 black and white men and women aged 70-79 y participating in the Health, Aging and Body Composition Study. Five-year changes in appendicular skeletal muscle mass (ASMM), total-body fat-free mass (FFM), and trunk lean mass (TLM) were measured by using dual-energy X-ray absorptiometry. Confounders included health and lifestyle factors, which are markers of inflammation and protein intake. Results: A low albumin concentration (<38 g/L) was observed in 21.2% of the study participants. After adjustment for confounders, the mean (±SE) change in ASMM was -82 ± 26 g per 3-g/L lower albumin concentration (P = 0.002). This association remained after persons with a low albumin concentration (<38 g/L) were excluded. The decline in ASMM in subjects with low albumin concentrations was almost 30% higher (-930 ± 56 g) than that in those with albumin concentrations ≥42 g/L (-718 ± 38 g; P < 0.01). The association between albumin and change in ASMM remained after additional adjustment for weight change. A weak association was observed for FFM, whereas no association was observed for TLM, which suggests a specific role of albumin in skeletal muscle change. Conclusions: Lower albumin concentrations, even above the clinical cutoff of 38 g/L, are associated with future loss of ASMM in older persons. Low albumin concentration may be a risk factor for sarcopenia.

Original languageEnglish (US)
Pages (from-to)531-537
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume82
Issue number3
StatePublished - Dec 1 2005

Fingerprint

Body Composition
Serum Albumin
Albumins
Muscles
Skeletal Muscle
Health
Sarcopenia
Photon Absorptiometry
Adipose Tissue
Life Style
Fats
Inflammation
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Visser, M., Kritchevsky, S. B., Newman, A. B., Goodpaster, B. H., Tylavsky, F., Nevitt, M. C., & Harris, T. B. (2005). Lower serum albumin concentration and change in muscle mass: The Health, Aging and Body Composition Study. American Journal of Clinical Nutrition, 82(3), 531-537.

Lower serum albumin concentration and change in muscle mass : The Health, Aging and Body Composition Study. / Visser, Marjolein; Kritchevsky, Stephen B.; Newman, Anne B.; Goodpaster, Bret H.; Tylavsky, Frances; Nevitt, Michael C.; Harris, Tamara B.

In: American Journal of Clinical Nutrition, Vol. 82, No. 3, 01.12.2005, p. 531-537.

Research output: Contribution to journalArticle

Visser, M, Kritchevsky, SB, Newman, AB, Goodpaster, BH, Tylavsky, F, Nevitt, MC & Harris, TB 2005, 'Lower serum albumin concentration and change in muscle mass: The Health, Aging and Body Composition Study', American Journal of Clinical Nutrition, vol. 82, no. 3, pp. 531-537.
Visser, Marjolein ; Kritchevsky, Stephen B. ; Newman, Anne B. ; Goodpaster, Bret H. ; Tylavsky, Frances ; Nevitt, Michael C. ; Harris, Tamara B. / Lower serum albumin concentration and change in muscle mass : The Health, Aging and Body Composition Study. In: American Journal of Clinical Nutrition. 2005 ; Vol. 82, No. 3. pp. 531-537.
@article{b4f359de2f744093af773f225e655252,
title = "Lower serum albumin concentration and change in muscle mass: The Health, Aging and Body Composition Study",
abstract = "Background: Low albumin concentrations in older persons increase the risk of poor health outcomes, including functional decline. Objective: The aim of the study was to investigate the association between serum albumin concentration and skeletal muscle loss (sarcopenia) in old age. Design: Serum albumin concentration was measured in 1882 black and white men and women aged 70-79 y participating in the Health, Aging and Body Composition Study. Five-year changes in appendicular skeletal muscle mass (ASMM), total-body fat-free mass (FFM), and trunk lean mass (TLM) were measured by using dual-energy X-ray absorptiometry. Confounders included health and lifestyle factors, which are markers of inflammation and protein intake. Results: A low albumin concentration (<38 g/L) was observed in 21.2{\%} of the study participants. After adjustment for confounders, the mean (±SE) change in ASMM was -82 ± 26 g per 3-g/L lower albumin concentration (P = 0.002). This association remained after persons with a low albumin concentration (<38 g/L) were excluded. The decline in ASMM in subjects with low albumin concentrations was almost 30{\%} higher (-930 ± 56 g) than that in those with albumin concentrations ≥42 g/L (-718 ± 38 g; P < 0.01). The association between albumin and change in ASMM remained after additional adjustment for weight change. A weak association was observed for FFM, whereas no association was observed for TLM, which suggests a specific role of albumin in skeletal muscle change. Conclusions: Lower albumin concentrations, even above the clinical cutoff of 38 g/L, are associated with future loss of ASMM in older persons. Low albumin concentration may be a risk factor for sarcopenia.",
author = "Marjolein Visser and Kritchevsky, {Stephen B.} and Newman, {Anne B.} and Goodpaster, {Bret H.} and Frances Tylavsky and Nevitt, {Michael C.} and Harris, {Tamara B.}",
year = "2005",
month = "12",
day = "1",
language = "English (US)",
volume = "82",
pages = "531--537",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "3",

}

TY - JOUR

T1 - Lower serum albumin concentration and change in muscle mass

T2 - The Health, Aging and Body Composition Study

AU - Visser, Marjolein

AU - Kritchevsky, Stephen B.

AU - Newman, Anne B.

AU - Goodpaster, Bret H.

AU - Tylavsky, Frances

AU - Nevitt, Michael C.

AU - Harris, Tamara B.

PY - 2005/12/1

Y1 - 2005/12/1

N2 - Background: Low albumin concentrations in older persons increase the risk of poor health outcomes, including functional decline. Objective: The aim of the study was to investigate the association between serum albumin concentration and skeletal muscle loss (sarcopenia) in old age. Design: Serum albumin concentration was measured in 1882 black and white men and women aged 70-79 y participating in the Health, Aging and Body Composition Study. Five-year changes in appendicular skeletal muscle mass (ASMM), total-body fat-free mass (FFM), and trunk lean mass (TLM) were measured by using dual-energy X-ray absorptiometry. Confounders included health and lifestyle factors, which are markers of inflammation and protein intake. Results: A low albumin concentration (<38 g/L) was observed in 21.2% of the study participants. After adjustment for confounders, the mean (±SE) change in ASMM was -82 ± 26 g per 3-g/L lower albumin concentration (P = 0.002). This association remained after persons with a low albumin concentration (<38 g/L) were excluded. The decline in ASMM in subjects with low albumin concentrations was almost 30% higher (-930 ± 56 g) than that in those with albumin concentrations ≥42 g/L (-718 ± 38 g; P < 0.01). The association between albumin and change in ASMM remained after additional adjustment for weight change. A weak association was observed for FFM, whereas no association was observed for TLM, which suggests a specific role of albumin in skeletal muscle change. Conclusions: Lower albumin concentrations, even above the clinical cutoff of 38 g/L, are associated with future loss of ASMM in older persons. Low albumin concentration may be a risk factor for sarcopenia.

AB - Background: Low albumin concentrations in older persons increase the risk of poor health outcomes, including functional decline. Objective: The aim of the study was to investigate the association between serum albumin concentration and skeletal muscle loss (sarcopenia) in old age. Design: Serum albumin concentration was measured in 1882 black and white men and women aged 70-79 y participating in the Health, Aging and Body Composition Study. Five-year changes in appendicular skeletal muscle mass (ASMM), total-body fat-free mass (FFM), and trunk lean mass (TLM) were measured by using dual-energy X-ray absorptiometry. Confounders included health and lifestyle factors, which are markers of inflammation and protein intake. Results: A low albumin concentration (<38 g/L) was observed in 21.2% of the study participants. After adjustment for confounders, the mean (±SE) change in ASMM was -82 ± 26 g per 3-g/L lower albumin concentration (P = 0.002). This association remained after persons with a low albumin concentration (<38 g/L) were excluded. The decline in ASMM in subjects with low albumin concentrations was almost 30% higher (-930 ± 56 g) than that in those with albumin concentrations ≥42 g/L (-718 ± 38 g; P < 0.01). The association between albumin and change in ASMM remained after additional adjustment for weight change. A weak association was observed for FFM, whereas no association was observed for TLM, which suggests a specific role of albumin in skeletal muscle change. Conclusions: Lower albumin concentrations, even above the clinical cutoff of 38 g/L, are associated with future loss of ASMM in older persons. Low albumin concentration may be a risk factor for sarcopenia.

UR - http://www.scopus.com/inward/record.url?scp=27244446077&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27244446077&partnerID=8YFLogxK

M3 - Article

VL - 82

SP - 531

EP - 537

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 3

ER -