Lyophilized veins as arterial interposition allografts

Mitchell Goldman, David A. Floering, Dennis R. French, Keith E. Gawith, Jerry D. Forgey, Douglas M. Strong

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Venous allografts were evaluated in two models. Lyophilized allograft veins used as interposition grafts in the infrarenal aorta of the canine were studied and found to be patent at 1 year. Pathologic examination of the grafts revealed mild intimal hyperplasia and persistence of the basic structure of the lyophilized vessel. The ability of venous tissue to elicit an antibody response when transplanted into an allogeneic recipient was studied in the rat using the lymphocyte cytotoxicity assay. Fresh and Me2SO-cryoprotected frozen veins produced circulating antibody when used as interposition grafts in the infrarenal aorta of the rat. Lyophilized and noncryoprotected frozen veins did not induce measurable antibody. Lyophilized allograft veins are a nonimmunogenic vascular graft material with acceptable long-term patency.

Original languageEnglish (US)
Pages (from-to)306-312
Number of pages7
JournalCryobiology
Volume18
Issue number3
DOIs
StatePublished - Jan 1 1981
Externally publishedYes

Fingerprint

allografting
Grafts
Allografts
Veins
aorta
Transplants
antibodies
Aorta
Antibodies
Rats
rats
patents
Tunica Intima
hyperplasia
blood vessels
Lymphocytes
cytotoxicity
lymphocytes
Cytotoxicity
Antibody Formation

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Goldman, M., Floering, D. A., French, D. R., Gawith, K. E., Forgey, J. D., & Strong, D. M. (1981). Lyophilized veins as arterial interposition allografts. Cryobiology, 18(3), 306-312. https://doi.org/10.1016/0011-2240(81)90102-4

Lyophilized veins as arterial interposition allografts. / Goldman, Mitchell; Floering, David A.; French, Dennis R.; Gawith, Keith E.; Forgey, Jerry D.; Strong, Douglas M.

In: Cryobiology, Vol. 18, No. 3, 01.01.1981, p. 306-312.

Research output: Contribution to journalArticle

Goldman, M, Floering, DA, French, DR, Gawith, KE, Forgey, JD & Strong, DM 1981, 'Lyophilized veins as arterial interposition allografts', Cryobiology, vol. 18, no. 3, pp. 306-312. https://doi.org/10.1016/0011-2240(81)90102-4
Goldman M, Floering DA, French DR, Gawith KE, Forgey JD, Strong DM. Lyophilized veins as arterial interposition allografts. Cryobiology. 1981 Jan 1;18(3):306-312. https://doi.org/10.1016/0011-2240(81)90102-4
Goldman, Mitchell ; Floering, David A. ; French, Dennis R. ; Gawith, Keith E. ; Forgey, Jerry D. ; Strong, Douglas M. / Lyophilized veins as arterial interposition allografts. In: Cryobiology. 1981 ; Vol. 18, No. 3. pp. 306-312.
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