Lysophospholipid Receptors

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The lysophospholipids (LPLs), including lysophosphatidic acid (radyl-lyso-glycerophosphate; LPA), 2,3-cyclic-phosphatidic acid, 1-alkyl-2-acetyl-glycero-3-phosphate, sphingosine-1-phosphate (S1P), dihydro-S1P, and sphingosylphosphorylcholine (lysosphingomyelin; SPC), exert some of their effects through specific plasma membrane and intracellular receptors. LPLs elicit cellular responses including promotion of cell survival, mitogenic/antimitogenic regulation of the cell cycle, effects on cell shape and motility, regulation of organotypic differentiation, modulation of immunological responses, and regulation of calcium homeostasis. In a pathological context, LPLs have been shown to play a role in lymphocyte recirculation, tumor cell invasion, angiogenesis, neointima formation, development of the heart ventricles, chemotherapeutic and radiation resistance, facial dysmorphism, nociception, and embryo implantation.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Biological Chemistry
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages762-764
Number of pages3
ISBN (Electronic)9780123786319
ISBN (Print)9780123786302
DOIs
StatePublished - Feb 15 2013

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Lysophospholipid Receptors
Lysophospholipids
Cells
Glycerophosphates
Neointima
Phosphatidic Acids
Nociception
Lymphocytes
Cell Shape
Cell membranes
Cytoplasmic and Nuclear Receptors
Heart Ventricles
Cell Movement
Tumors
Cell Survival
Cell Cycle
Phosphates
Homeostasis
Cell Membrane
Modulation

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Tigyi, G. (2013). Lysophospholipid Receptors. In Encyclopedia of Biological Chemistry: Second Edition (pp. 762-764). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-378630-2.00465-5

Lysophospholipid Receptors. / Tigyi, Gabor.

Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc., 2013. p. 762-764.

Research output: Chapter in Book/Report/Conference proceedingChapter

Tigyi, G 2013, Lysophospholipid Receptors. in Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc., pp. 762-764. https://doi.org/10.1016/B978-0-12-378630-2.00465-5
Tigyi G. Lysophospholipid Receptors. In Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc. 2013. p. 762-764 https://doi.org/10.1016/B978-0-12-378630-2.00465-5
Tigyi, Gabor. / Lysophospholipid Receptors. Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc., 2013. pp. 762-764
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