Lysophospholipid signaling

Beyond the EDGs

William J. Valentine, Yuko Fujiwara, Ryoko Tsukahara, Gabor Tigyi

Research output: Contribution to journalReview article

23 Citations (Scopus)

Abstract

As our understanding of the myriads of biological effects caused by lysophospholipids expands, we become witnesses to another miracle of nature that has endowed the simplest lysophospholipids with functions seemingly ubiquitous to every mammalian cell. A decade after the discovery of the EDG family lysophospholipid receptors, the field has gained unimaginable impetus explaining the biological effects of sphingosine-1-phosphate and lysophosphatidic acid (LPA). The discovery of LPA receptors in the purinergic G-protein-coupled receptor (GPCR) gene cluster refined this picture and added complexity to our concepts of lysophospholipid cell signaling. The intracellular lysophospholipid targets - identified and not yet identified - make us realize the dual mediator and second messenger roles of lysophospholipids. In this paper we provide new data obtained concerning LPA-elicited responses using cell lines naturally lacking or intentionally knocked out of many of the known LPA GPCR, widely used by investigators in the field as cells with LPA receptor "null background." Our observations raise caution about the lack of LPA responsiveness in these cells and underline the unprecedented complexity and redundancy of lysophospholipid-evoked cellular responses.

Original languageEnglish (US)
Pages (from-to)597-605
Number of pages9
JournalBiochimica et Biophysica Acta - General Subjects
Volume1780
Issue number3
DOIs
StatePublished - Mar 1 2008

Fingerprint

Lysophospholipids
Lysophosphatidic Acid Receptors
G-Protein-Coupled Receptors
Lysophospholipid Receptors
Cells
Cell signaling
Second Messenger Systems
Multigene Family
Redundancy
Genes
Research Personnel
Cell Line
lysophosphatidic acid

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Lysophospholipid signaling : Beyond the EDGs. / Valentine, William J.; Fujiwara, Yuko; Tsukahara, Ryoko; Tigyi, Gabor.

In: Biochimica et Biophysica Acta - General Subjects, Vol. 1780, No. 3, 01.03.2008, p. 597-605.

Research output: Contribution to journalReview article

Valentine, William J. ; Fujiwara, Yuko ; Tsukahara, Ryoko ; Tigyi, Gabor. / Lysophospholipid signaling : Beyond the EDGs. In: Biochimica et Biophysica Acta - General Subjects. 2008 ; Vol. 1780, No. 3. pp. 597-605.
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