Macroporous biodegradable polymer scaffold using gas forming salt as porogen additive

Novel fabrication method for cartilage engineering

Hongsik Cho, Tea Gwan Park, So Ra Park, Byoung Hyun Min

Research output: Contribution to conferencePaper

1 Citation (Scopus)

Abstract

The use of macroporous biodegradable polymer scaffold using gas forming salt for cartilage engineering was investigated. PLGA paste containing ammonium bicarbonate particulates, acting as a gas forming agent and a salt leaching porogen were used to fabricate highly porous biodegradable scaffolds. Rabbit articular chondrocytes suspension with density from 2 to 5x105 cells/mm3 was attached onto the scaffold in modified flask with stirrer. The results showed well-adhered and evenly spread chondrocytes onto the surface of macropores for 10 days of culture in bioreactor. This cost-effective and simple method is expected to have potential applications for cartilage regeneration.

Original languageEnglish (US)
Number of pages1
StatePublished - Dec 1 2000
Externally publishedYes
EventSecond Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling - York, United Kingdom
Duration: Jul 16 2000Jul 19 2000

Other

OtherSecond Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling
CountryUnited Kingdom
CityYork
Period7/16/007/19/00

Fingerprint

Biodegradable polymers
Cartilage
Scaffolds
Salts
Fabrication
Ammonium bicarbonate
Gases
Bioreactors
Leaching
Costs

All Science Journal Classification (ASJC) codes

  • Engineering(all)

Cite this

Cho, H., Park, T. G., Park, S. R., & Min, B. H. (2000). Macroporous biodegradable polymer scaffold using gas forming salt as porogen additive: Novel fabrication method for cartilage engineering. Paper presented at Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling, York, United Kingdom.

Macroporous biodegradable polymer scaffold using gas forming salt as porogen additive : Novel fabrication method for cartilage engineering. / Cho, Hongsik; Park, Tea Gwan; Park, So Ra; Min, Byoung Hyun.

2000. Paper presented at Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling, York, United Kingdom.

Research output: Contribution to conferencePaper

Cho, H, Park, TG, Park, SR & Min, BH 2000, 'Macroporous biodegradable polymer scaffold using gas forming salt as porogen additive: Novel fabrication method for cartilage engineering' Paper presented at Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling, York, United Kingdom, 7/16/00 - 7/19/00, .
Cho H, Park TG, Park SR, Min BH. Macroporous biodegradable polymer scaffold using gas forming salt as porogen additive: Novel fabrication method for cartilage engineering. 2000. Paper presented at Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling, York, United Kingdom.
Cho, Hongsik ; Park, Tea Gwan ; Park, So Ra ; Min, Byoung Hyun. / Macroporous biodegradable polymer scaffold using gas forming salt as porogen additive : Novel fabrication method for cartilage engineering. Paper presented at Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling, York, United Kingdom.1 p.
@conference{18c4bfdfc41c4c45bc9ffbe399f05d56,
title = "Macroporous biodegradable polymer scaffold using gas forming salt as porogen additive: Novel fabrication method for cartilage engineering",
abstract = "The use of macroporous biodegradable polymer scaffold using gas forming salt for cartilage engineering was investigated. PLGA paste containing ammonium bicarbonate particulates, acting as a gas forming agent and a salt leaching porogen were used to fabricate highly porous biodegradable scaffolds. Rabbit articular chondrocytes suspension with density from 2 to 5x105 cells/mm3 was attached onto the scaffold in modified flask with stirrer. The results showed well-adhered and evenly spread chondrocytes onto the surface of macropores for 10 days of culture in bioreactor. This cost-effective and simple method is expected to have potential applications for cartilage regeneration.",
author = "Hongsik Cho and Park, {Tea Gwan} and Park, {So Ra} and Min, {Byoung Hyun}",
year = "2000",
month = "12",
day = "1",
language = "English (US)",
note = "Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling ; Conference date: 16-07-2000 Through 19-07-2000",

}

TY - CONF

T1 - Macroporous biodegradable polymer scaffold using gas forming salt as porogen additive

T2 - Novel fabrication method for cartilage engineering

AU - Cho, Hongsik

AU - Park, Tea Gwan

AU - Park, So Ra

AU - Min, Byoung Hyun

PY - 2000/12/1

Y1 - 2000/12/1

N2 - The use of macroporous biodegradable polymer scaffold using gas forming salt for cartilage engineering was investigated. PLGA paste containing ammonium bicarbonate particulates, acting as a gas forming agent and a salt leaching porogen were used to fabricate highly porous biodegradable scaffolds. Rabbit articular chondrocytes suspension with density from 2 to 5x105 cells/mm3 was attached onto the scaffold in modified flask with stirrer. The results showed well-adhered and evenly spread chondrocytes onto the surface of macropores for 10 days of culture in bioreactor. This cost-effective and simple method is expected to have potential applications for cartilage regeneration.

AB - The use of macroporous biodegradable polymer scaffold using gas forming salt for cartilage engineering was investigated. PLGA paste containing ammonium bicarbonate particulates, acting as a gas forming agent and a salt leaching porogen were used to fabricate highly porous biodegradable scaffolds. Rabbit articular chondrocytes suspension with density from 2 to 5x105 cells/mm3 was attached onto the scaffold in modified flask with stirrer. The results showed well-adhered and evenly spread chondrocytes onto the surface of macropores for 10 days of culture in bioreactor. This cost-effective and simple method is expected to have potential applications for cartilage regeneration.

UR - http://www.scopus.com/inward/record.url?scp=18644370717&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18644370717&partnerID=8YFLogxK

M3 - Paper

ER -