Magnesium attenuates pulmonary hypertension due to hypoxia and group B streptococci

M. E. Anderson, Tara Burnette, D. R. Geiser, W. Janjindamai

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Abstract

We investigated whether hypermagnesemia alleviates hypoxic or group B streptococcal (GBS) pulmonary hypertension (PH). Hypoxic PH was induced and maintained in 14 lambs by continuous ventilation with 12% oxygen. GBS PH was induced and maintained in 16 lambs by the continuous infusion of 5-10 x 108 colony-forming units · kg-1 · h-1 of GBS. After the onset of PH, lambs were randomized to receive either magnesium sulfate (MgSO4, intermittent boluses of 0.38 mmol/kg, with a continuous infusion of 0.15 mmol · kg-1 · h-1) or a similar volume of normal saline. Hypermagnesemia lowered pulmonary arterial pressure (PAP) and delayed the fall in systemic arterial pressure and stroke volume index seen in the control animals (each P < 0.05). At a serum magnesium concentration ([Mg]) of 2.75 ± 0.25 mmol/l, PAP was 27 ± 3 compared with 40 ± 4 Torr in the control animals ([Mg] = 0.87 ± 0.06 mmol/l; P < 0.05). In the GBS PH trial, hypermagnesemia prevented the continued increase in PAP seen in the control animals. At [Mg] = 2.15 ± 0.07 mmol/l, PAP fell 2 ± 1 Torr from prerandomization values, whereas it rose 4 ± 2 Torr in the control animals ([Mg] = 0.59 ± 0.07 mmol/l; P < 0.05). However, during the same time the systemic arterial pressure fell further in the magnesium-treated animals (-19 ± 1 vs. -2 ± 5 Torr). MgSO4 attenuates PH in both models but may cause systemic hypotension in sepsis.

Original languageEnglish (US)
Pages (from-to)751-756
Number of pages6
JournalJournal of Applied Physiology
Volume77
Issue number2
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

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Streptococcus agalactiae
Pulmonary Hypertension
Magnesium
Arterial Pressure
Lung
Magnesium Sulfate
Stroke Volume
Hypotension
Ventilation
Hypoxia
Sepsis
Stem Cells
Oxygen
Serum

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

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Magnesium attenuates pulmonary hypertension due to hypoxia and group B streptococci. / Anderson, M. E.; Burnette, Tara; Geiser, D. R.; Janjindamai, W.

In: Journal of Applied Physiology, Vol. 77, No. 2, 01.01.1994, p. 751-756.

Research output: Contribution to journalArticle

Anderson, M. E. ; Burnette, Tara ; Geiser, D. R. ; Janjindamai, W. / Magnesium attenuates pulmonary hypertension due to hypoxia and group B streptococci. In: Journal of Applied Physiology. 1994 ; Vol. 77, No. 2. pp. 751-756.
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