Magnetic resonance imaging reveals Creutzfeldt-Jakob disease in a patient with apparent dementia with Lewy bodies

Georgios Tsivgoulis, Anastasios Bonakis, Matilda A. Papathanasiou, Maria Chondrogianni, Sokratis G. Papageorgiou, Konstantinos Voumvourakis, Leonidas Stefanis

Research output: Contribution to journalArticle

Abstract

The differential diagnosis of dementia with Lewy bodies (DLB) and sporadic Creutzfeldt-Jakob disease (CJD) may be challenging. Patients with the original diagnosis of possible CJD may occasionally prove to have a pathological diagnosis of DLB, while other cases may fulfill the diagnostic clinical criteria for DLB but subsequent clinical course, cerebrospinal fluid (CSF) and neuropathology findings necessitate diagnostic revision to CJD. We describe a 79-year old patient recently diagnosed with dementia with Lewy bodies (DLB) on the basis of subacute cognitive decline, visual hallucinations and Parkinsonian features, who presented with increasing agitation. Brain neuroimaging with MRI raised the diagnostic suspicion of CJD and subsequent diagnostic work-up with electroencephalography (EEG) and CSF analysis led to the establishment of CJD diagnosis. The present case highlights the clinical utility of novel diagnostic CJD criteria that also incorporate neuroimaging findings in the diagnostic CJD panel.

Original languageEnglish (US)
Pages (from-to)130-132
Number of pages3
JournalJournal of the Neurological Sciences
Volume340
Issue number1-2
DOIs
StatePublished - May 15 2014

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Lewy Body Disease
Creutzfeldt-Jakob Syndrome
Magnetic Resonance Imaging
Neuroimaging
Cerebrospinal Fluid
Hallucinations
Electroencephalography
Differential Diagnosis
Brain

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Tsivgoulis, G., Bonakis, A., Papathanasiou, M. A., Chondrogianni, M., Papageorgiou, S. G., Voumvourakis, K., & Stefanis, L. (2014). Magnetic resonance imaging reveals Creutzfeldt-Jakob disease in a patient with apparent dementia with Lewy bodies. Journal of the Neurological Sciences, 340(1-2), 130-132. https://doi.org/10.1016/j.jns.2014.03.010

Magnetic resonance imaging reveals Creutzfeldt-Jakob disease in a patient with apparent dementia with Lewy bodies. / Tsivgoulis, Georgios; Bonakis, Anastasios; Papathanasiou, Matilda A.; Chondrogianni, Maria; Papageorgiou, Sokratis G.; Voumvourakis, Konstantinos; Stefanis, Leonidas.

In: Journal of the Neurological Sciences, Vol. 340, No. 1-2, 15.05.2014, p. 130-132.

Research output: Contribution to journalArticle

Tsivgoulis, G, Bonakis, A, Papathanasiou, MA, Chondrogianni, M, Papageorgiou, SG, Voumvourakis, K & Stefanis, L 2014, 'Magnetic resonance imaging reveals Creutzfeldt-Jakob disease in a patient with apparent dementia with Lewy bodies', Journal of the Neurological Sciences, vol. 340, no. 1-2, pp. 130-132. https://doi.org/10.1016/j.jns.2014.03.010
Tsivgoulis, Georgios ; Bonakis, Anastasios ; Papathanasiou, Matilda A. ; Chondrogianni, Maria ; Papageorgiou, Sokratis G. ; Voumvourakis, Konstantinos ; Stefanis, Leonidas. / Magnetic resonance imaging reveals Creutzfeldt-Jakob disease in a patient with apparent dementia with Lewy bodies. In: Journal of the Neurological Sciences. 2014 ; Vol. 340, No. 1-2. pp. 130-132.
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