Malignant granular cell tumor of the back

A case report and review of the literature

Laura Stone McGuire, Danny Yakoub, Mecker G. Möller, Andrew Rosenberg, Alan Livingstone

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Malignant granular cell tumors are rare, intensely aggressive entities. This paper presents a case of a large rapidly recurrent malignant granular cell tumor with regional and distal metastases on the back of a 54-year-old Cuban man. The primary tumor recurred within six months of the original wide local excision and with satellite lesions apparent at twelve months, and the mass was diagnosed using the histological criteria established by Fanburg-Smith et al. for malignant granular cell tumors. By fifteen months, right axillary lymphadenopathy, multiple satellite lesions, pulmonary nodules, and distant metastasis in the right thigh were present. At sixteen months, wide local excision of recurrent mass and local satellite masses along with right axillary dissection and placement of Integra with subsequent split-thickness skin graft were performed by surgical oncology and plastic surgery teams. The surgical specimen measured 32.0 × 13.5 × 5.5 cm, containing multiple homogeneous masses with the largest mass 22.0 × 9.0 × 4.6 cm. Following surgery, patient was started on Pazopanib 800 mg/day based on phase III randomized trial data in the treatment of soft tissue sarcomas showing this as a potential novel therapy for malignant granular cell tumors.

Original languageEnglish (US)
Article number794648
JournalCase Reports in Medicine
Volume2014
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

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Granular Cell Tumor
Neoplasm Metastasis
Plastic Surgery
Thigh
Sarcoma
Dissection
Transplants
Lung
Skin
Therapeutics
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Malignant granular cell tumor of the back : A case report and review of the literature. / McGuire, Laura Stone; Yakoub, Danny; Möller, Mecker G.; Rosenberg, Andrew; Livingstone, Alan.

In: Case Reports in Medicine, Vol. 2014, 794648, 01.01.2014.

Research output: Contribution to journalArticle

McGuire, Laura Stone ; Yakoub, Danny ; Möller, Mecker G. ; Rosenberg, Andrew ; Livingstone, Alan. / Malignant granular cell tumor of the back : A case report and review of the literature. In: Case Reports in Medicine. 2014 ; Vol. 2014.
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