Malignant transformation of irradiated craniopharyngioma in children

Report of 2 cases

Kristian Aquilina, Thomas Merchant, Carlos Rodriguez-Galindo, David W. Ellison, Robert A. Sanford, Frederick Boop

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Malignant transformation of craniopharyngioma is a rare event; only 3 cases have been reported in children, all in the Japanese literature. The authors describe 2 additional pediatric cases. Treatment in both of these cases consisted of multiple resections and external beam radiation therapy (EBRT). Malignant transformation occurred 7 and 8 years after EBRT. The authors also review another 6 cases in adults. A possible causative association with radiation therapy is discussed. As radiation is currently an important option in the management of craniopharyngiomas, this association requires further study.

Original languageEnglish (US)
Pages (from-to)155-161
Number of pages7
JournalJournal of Neurosurgery: Pediatrics
Volume5
Issue number2
DOIs
StatePublished - Feb 1 2010

Fingerprint

Craniopharyngioma
Radiotherapy
Radiation
Pediatrics
Therapeutics

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

Malignant transformation of irradiated craniopharyngioma in children : Report of 2 cases. / Aquilina, Kristian; Merchant, Thomas; Rodriguez-Galindo, Carlos; Ellison, David W.; Sanford, Robert A.; Boop, Frederick.

In: Journal of Neurosurgery: Pediatrics, Vol. 5, No. 2, 01.02.2010, p. 155-161.

Research output: Contribution to journalArticle

Aquilina, Kristian ; Merchant, Thomas ; Rodriguez-Galindo, Carlos ; Ellison, David W. ; Sanford, Robert A. ; Boop, Frederick. / Malignant transformation of irradiated craniopharyngioma in children : Report of 2 cases. In: Journal of Neurosurgery: Pediatrics. 2010 ; Vol. 5, No. 2. pp. 155-161.
@article{734fd2fe61dd4c01bf30b9e0abe55743,
title = "Malignant transformation of irradiated craniopharyngioma in children: Report of 2 cases",
abstract = "Malignant transformation of craniopharyngioma is a rare event; only 3 cases have been reported in children, all in the Japanese literature. The authors describe 2 additional pediatric cases. Treatment in both of these cases consisted of multiple resections and external beam radiation therapy (EBRT). Malignant transformation occurred 7 and 8 years after EBRT. The authors also review another 6 cases in adults. A possible causative association with radiation therapy is discussed. As radiation is currently an important option in the management of craniopharyngiomas, this association requires further study.",
author = "Kristian Aquilina and Thomas Merchant and Carlos Rodriguez-Galindo and Ellison, {David W.} and Sanford, {Robert A.} and Frederick Boop",
year = "2010",
month = "2",
day = "1",
doi = "10.3171/2009.9.PEDS09257",
language = "English (US)",
volume = "5",
pages = "155--161",
journal = "Journal of Neurosurgery: Pediatrics",
issn = "1933-0707",
publisher = "American Association of Neurological Surgeons",
number = "2",

}

TY - JOUR

T1 - Malignant transformation of irradiated craniopharyngioma in children

T2 - Report of 2 cases

AU - Aquilina, Kristian

AU - Merchant, Thomas

AU - Rodriguez-Galindo, Carlos

AU - Ellison, David W.

AU - Sanford, Robert A.

AU - Boop, Frederick

PY - 2010/2/1

Y1 - 2010/2/1

N2 - Malignant transformation of craniopharyngioma is a rare event; only 3 cases have been reported in children, all in the Japanese literature. The authors describe 2 additional pediatric cases. Treatment in both of these cases consisted of multiple resections and external beam radiation therapy (EBRT). Malignant transformation occurred 7 and 8 years after EBRT. The authors also review another 6 cases in adults. A possible causative association with radiation therapy is discussed. As radiation is currently an important option in the management of craniopharyngiomas, this association requires further study.

AB - Malignant transformation of craniopharyngioma is a rare event; only 3 cases have been reported in children, all in the Japanese literature. The authors describe 2 additional pediatric cases. Treatment in both of these cases consisted of multiple resections and external beam radiation therapy (EBRT). Malignant transformation occurred 7 and 8 years after EBRT. The authors also review another 6 cases in adults. A possible causative association with radiation therapy is discussed. As radiation is currently an important option in the management of craniopharyngiomas, this association requires further study.

UR - http://www.scopus.com/inward/record.url?scp=76149113218&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=76149113218&partnerID=8YFLogxK

U2 - 10.3171/2009.9.PEDS09257

DO - 10.3171/2009.9.PEDS09257

M3 - Article

VL - 5

SP - 155

EP - 161

JO - Journal of Neurosurgery: Pediatrics

JF - Journal of Neurosurgery: Pediatrics

SN - 1933-0707

IS - 2

ER -