Mammographic Density

Intersection of Advocacy, Science, and Clinical Practice

Katherine Tossas-Milligan, Sundus Shalabi, Veronica Jones, Patricia J. Keely, Matthew W. Conklin, Kevin W. Eliceiri, Robert Winn, Christopher Sistrunk, Joseph Geradts, Gustavo Miranda-Carboni, Eric C. Dietze, Lisa D. Yee, Victoria L. Seewaldt

Research output: Contribution to journalReview article

Abstract

Purpose of Review: Here we aim to review the association between mammographic density, collagen structure, and breast cancer risk. Recent Findings: While mammographic density is a strong predictor of breast cancer risk in populations, studies by Boyd show that mammographic density does not predict breast cancer risk in individuals. Mammographic density is affected by age, parity, menopausal status, race/ethnicity, and body mass index (BMI). New studies normalize mammographic density to BMI and this may provide a more accurate way to compare mammographic density in women of diverse race and ethnicity. Preclinical and tissue-based studies have investigated the role collagen composition and structure in predicting breast cancer risk. There is emerging evidence that collagen structure may activate signaling pathways associated with aggressive breast cancer biology. Summary: Measurement of film mammographic density does not adequately capture the complex signaling that occurs in women with at-risk collagen. New ways to measure at-risk collagen potentially can provide a more accurate view of risk.

Original languageEnglish (US)
JournalCurrent Breast Cancer Reports
DOIs
StatePublished - Jan 1 2019

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Collagen
Breast Neoplasms
Body Mass Index
Parity
Breast Density
Population

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

Tossas-Milligan, K., Shalabi, S., Jones, V., Keely, P. J., Conklin, M. W., Eliceiri, K. W., ... Seewaldt, V. L. (2019). Mammographic Density: Intersection of Advocacy, Science, and Clinical Practice. Current Breast Cancer Reports. https://doi.org/10.1007/s12609-019-00316-4

Mammographic Density : Intersection of Advocacy, Science, and Clinical Practice. / Tossas-Milligan, Katherine; Shalabi, Sundus; Jones, Veronica; Keely, Patricia J.; Conklin, Matthew W.; Eliceiri, Kevin W.; Winn, Robert; Sistrunk, Christopher; Geradts, Joseph; Miranda-Carboni, Gustavo; Dietze, Eric C.; Yee, Lisa D.; Seewaldt, Victoria L.

In: Current Breast Cancer Reports, 01.01.2019.

Research output: Contribution to journalReview article

Tossas-Milligan, K, Shalabi, S, Jones, V, Keely, PJ, Conklin, MW, Eliceiri, KW, Winn, R, Sistrunk, C, Geradts, J, Miranda-Carboni, G, Dietze, EC, Yee, LD & Seewaldt, VL 2019, 'Mammographic Density: Intersection of Advocacy, Science, and Clinical Practice', Current Breast Cancer Reports. https://doi.org/10.1007/s12609-019-00316-4
Tossas-Milligan, Katherine ; Shalabi, Sundus ; Jones, Veronica ; Keely, Patricia J. ; Conklin, Matthew W. ; Eliceiri, Kevin W. ; Winn, Robert ; Sistrunk, Christopher ; Geradts, Joseph ; Miranda-Carboni, Gustavo ; Dietze, Eric C. ; Yee, Lisa D. ; Seewaldt, Victoria L. / Mammographic Density : Intersection of Advocacy, Science, and Clinical Practice. In: Current Breast Cancer Reports. 2019.
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