Management of anticoagulation and hemostasis for pediatric extracorporeal membrane oxygenation

Arun Saini, Philip C. Spinella

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

Compared to in situ vascular physiology where pro and anti-hemostatic processes are in balance to maintain hemostasis, the use of ECMO in a critically ill child increases the risk of hemorrhagic or thromboembolic events due to a perturbation in the balance inherent of this complex system. The ECMO circuit has pro-hemostatic effects due to contact activation of hemostasis and inflammatory pathways. In addition, the critical illness of the child can cause dysregulation of hemostasis that may shift between hyper and hypocoagulable states over time.

Original languageEnglish (US)
Pages (from-to)655-673
Number of pages19
JournalClinics in Laboratory Medicine
Volume34
Issue number3
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

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Extracorporeal Membrane Oxygenation
Pediatrics
Oxygenation
Hemostatics
Hemostasis
Membranes
Critical Illness
Physiology
Large scale systems
Chemical activation
Blood Vessels
Networks (circuits)

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Management of anticoagulation and hemostasis for pediatric extracorporeal membrane oxygenation. / Saini, Arun; Spinella, Philip C.

In: Clinics in Laboratory Medicine, Vol. 34, No. 3, 01.01.2014, p. 655-673.

Research output: Contribution to journalReview article

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