Management of oral epithelial dysplasia

a review

Michael Brennan, Cesar Migliorati, Peter B. Lockhart, David Wray, Ibtisam Al-Hashimi, Tony Axéll, Alison J. Bruce, William Carpenter, Ellen Eisenberg, Joel B. Epstein, Palle Holmstrup, Mats Jontell, Raj Nair, Howell Sasser, Mark Schifter, (Sol) Bud Silverman, Kobkan Thongprasom, Martin Thornhill, Saman Warnakulasuriya, Isaäc van der Waal

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

One of the goals of the fourth meeting of The World Workshop on Oral Medicine (WWOM IV) included a review of the pathophysiology and future directions for the clinical management of patients with oral epithelial dysplasia, excluding the lips and oropharynx. In the pathophysiology review of dysplasia since WWOM III (1998-2006), a wide range of molecular changes associated with progression of dysplasia to squamous cell carcinoma were found. These include loss of heterozygosity, dysregulation of apoptosis, aberrant DNA expression, and altered expression of numerous tissue markers. Based on the literature search, no single molecular pathway has been identified as the primary factor in progression of dysplasia to squamous cell carcinoma. A systematic review of medical (i.e., nonsurgical) management strategies for the treatment of dysplastic lesions has shown promising results in short-term resolution of dysplasia in the small number of studies that met eligibility criteria for review. However, because of the limited periods of follow-up reported in these studies, it remains unclear as whether resolution of dysplasia would actually be a long-term benefit of these interventions. This question is particularly germane when it is considered in the context of prevention of future development of squamous cell carcinoma. Because of the lack of randomized controlled trials that have shown effectiveness in the prevention of malignant transformation, no recommendations can be provided for specific surgical interventions of dysplastic oral lesions either.

Original languageEnglish (US)
Pages (from-to)S19.e1-S19.e12
JournalOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology
Volume103
Issue numberSUPPL.
DOIs
StatePublished - Jan 1 2007

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Squamous Cell Carcinoma
Oral Medicine
Oropharynx
Loss of Heterozygosity
Lip
Randomized Controlled Trials
Apoptosis
Education
DNA
Therapeutics
Direction compound

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology
  • Dentistry(all)

Cite this

Brennan, M., Migliorati, C., Lockhart, P. B., Wray, D., Al-Hashimi, I., Axéll, T., ... van der Waal, I. (2007). Management of oral epithelial dysplasia: a review. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, 103(SUPPL.), S19.e1-S19.e12. https://doi.org/10.1016/j.tripleo.2006.10.015

Management of oral epithelial dysplasia : a review. / Brennan, Michael; Migliorati, Cesar; Lockhart, Peter B.; Wray, David; Al-Hashimi, Ibtisam; Axéll, Tony; Bruce, Alison J.; Carpenter, William; Eisenberg, Ellen; Epstein, Joel B.; Holmstrup, Palle; Jontell, Mats; Nair, Raj; Sasser, Howell; Schifter, Mark; Silverman, (Sol) Bud; Thongprasom, Kobkan; Thornhill, Martin; Warnakulasuriya, Saman; van der Waal, Isaäc.

In: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, Vol. 103, No. SUPPL., 01.01.2007, p. S19.e1-S19.e12.

Research output: Contribution to journalArticle

Brennan, M, Migliorati, C, Lockhart, PB, Wray, D, Al-Hashimi, I, Axéll, T, Bruce, AJ, Carpenter, W, Eisenberg, E, Epstein, JB, Holmstrup, P, Jontell, M, Nair, R, Sasser, H, Schifter, M, Silverman, SB, Thongprasom, K, Thornhill, M, Warnakulasuriya, S & van der Waal, I 2007, 'Management of oral epithelial dysplasia: a review', Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, vol. 103, no. SUPPL., pp. S19.e1-S19.e12. https://doi.org/10.1016/j.tripleo.2006.10.015
Brennan M, Migliorati C, Lockhart PB, Wray D, Al-Hashimi I, Axéll T et al. Management of oral epithelial dysplasia: a review. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology. 2007 Jan 1;103(SUPPL.):S19.e1-S19.e12. https://doi.org/10.1016/j.tripleo.2006.10.015
Brennan, Michael ; Migliorati, Cesar ; Lockhart, Peter B. ; Wray, David ; Al-Hashimi, Ibtisam ; Axéll, Tony ; Bruce, Alison J. ; Carpenter, William ; Eisenberg, Ellen ; Epstein, Joel B. ; Holmstrup, Palle ; Jontell, Mats ; Nair, Raj ; Sasser, Howell ; Schifter, Mark ; Silverman, (Sol) Bud ; Thongprasom, Kobkan ; Thornhill, Martin ; Warnakulasuriya, Saman ; van der Waal, Isaäc. / Management of oral epithelial dysplasia : a review. In: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology. 2007 ; Vol. 103, No. SUPPL. pp. S19.e1-S19.e12.
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