Managing severe epilepsy syndromes of early childhood

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Managing severe epilepsy syndromes of early childhood is challenging as the seizures are typically resistant to treatment and may cause disabling mental and behavioral problems in later life. A comprehensive treatment plan includes pharmacologic, nonpharmacologic, and surgical options. This article reviews clinical studies examining the efficacies of antiepileptic medications in reducing seizure frequency in Dravet syndrome, Doose syndrome, and Lennox-Gastaut syndrome. The benefits of the ketogenic diet for children with these severe epilepsies, together with the advantages of vagus nerve stimulation and corpus callosotomy in those patients with Lennox-Gastaut syndrome, are also discussed. Special treatment considerations for each syndrome are also highlighted to improve the management of patients with these syndromes.

Original languageEnglish (US)
JournalJournal of child neurology
Volume24
Issue number8
DOIs
StatePublished - Aug 18 2009

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Epilepsy
Seizures
Ketogenic Diet
Myoclonic Epilepsy
Vagus Nerve Stimulation
Anticonvulsants
Therapeutics
Lennox Gastaut Syndrome

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

Managing severe epilepsy syndromes of early childhood. / Wheless, James.

In: Journal of child neurology, Vol. 24, No. 8, 18.08.2009.

Research output: Contribution to journalArticle

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