Manganese neurotoxicity

behavioral disorders associated with dysfunctions in the basal ganglia and neurochemical transmission

Safa Bouabid, Anass Tinakoua, Nouria Lakhdar-Ghazal, Abdelhamid Benazzouz

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

Manganese (Mn) is an essential element required for many physiological functions. While it is essential at physiological levels, excessive accumulation of Mn in the brain causes severe dysfunctions in the central nervous system known as manganism. Manganism is an extrapyramidal disorder characterized by motor disturbances associated with neuropsychiatric and cognitive disabilities similar to Parkinsonism. As the primary brain regions targeted by Mn are the basal ganglia, known to be involved in the pathophysiology of extrapyramidal disorders, this review will examine the impact of Mn exposure on the basal ganglia circuitry and neurotransmitters in relation to motor and non-motor disorders. The collected data from recent available studies in humans and experimental animal models provide new information about the mechanisms by which Mn affects behavior, neurotransmitters, and basal ganglia function observed in manganism. The effects of the alterations of metals on basal ganglia and neurochemical functioning are critical to develop effective modalities not only for the treatment of vulnerable populations (e.g., Mn-exposed workers) but also for understanding the etiology of neurodegenerative diseases where brain metal imbalances are involved, such as Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)677-691
Number of pages15
JournalJournal of Neurochemistry
Volume136
Issue number4
DOIs
StatePublished - Feb 1 2016

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Manganese
Basal Ganglia
Basal Ganglia Diseases
Brain
Neurotransmitter Agents
Metals
Neurodegenerative diseases
Parkinsonian Disorders
Neurology
Vulnerable Populations
Neurodegenerative Diseases
Parkinson Disease
Animals
Central Nervous System
Animal Models

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Manganese neurotoxicity : behavioral disorders associated with dysfunctions in the basal ganglia and neurochemical transmission. / Bouabid, Safa; Tinakoua, Anass; Lakhdar-Ghazal, Nouria; Benazzouz, Abdelhamid.

In: Journal of Neurochemistry, Vol. 136, No. 4, 01.02.2016, p. 677-691.

Research output: Contribution to journalReview article

Bouabid, Safa ; Tinakoua, Anass ; Lakhdar-Ghazal, Nouria ; Benazzouz, Abdelhamid. / Manganese neurotoxicity : behavioral disorders associated with dysfunctions in the basal ganglia and neurochemical transmission. In: Journal of Neurochemistry. 2016 ; Vol. 136, No. 4. pp. 677-691.
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