Mapping of provisional quantitative trait loci influencing temporal variation in locomotor activity in the LS X SS recombinant inbred strains

Richard A. Radcliffe, Byron Jones, V. Gene Erwin

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The finding that stress-induced locomotor activity exhibited a significant strain X time interaction in the LS x SS RI strains prompted examination of QTL influencing this behavior as a function of time. The degree of genetic determination for locomotor activity was 0.26 for the first 5 rain and decreased to 0.16 for the last 5 min of a 30-min test but the number of genetic factors stayed relatively constant (three or four) across time. A QTL point analysis revealed a total of 15 QTL, 5-8 per 5-min time block. Few of the QTL were detected across all time points and different combinations of QTL were evident for each time period. Five of the QTL were in common with those reported by other investigators for similar behaviors. The results suggest that locomotor behavior is under a greater degree of genetic control during the initial part of the test but environmental factors become increasingly important as the test progresses. Furthermore, different genetic factors appear to be mediating genetic variation in locomotor behavior at any given time point.

Original languageEnglish (US)
Pages (from-to)39-47
Number of pages9
JournalBehavior Genetics
Volume28
Issue number1
DOIs
StatePublished - Apr 27 1998

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Quantitative Trait Loci
Locomotion
locomotion
temporal variation
quantitative trait loci
testing
Rain
genetic variation
environmental factor
rain
Research Personnel
environmental factors
test

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Genetics(clinical)

Cite this

Mapping of provisional quantitative trait loci influencing temporal variation in locomotor activity in the LS X SS recombinant inbred strains. / Radcliffe, Richard A.; Jones, Byron; Erwin, V. Gene.

In: Behavior Genetics, Vol. 28, No. 1, 27.04.1998, p. 39-47.

Research output: Contribution to journalArticle

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